Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Characterization of the gas explosion under continuous disturbance by coal gangue in a coal mine gob
Gas explosions in coal mine gobs caused by the spontaneous combustion of coal usually result in serious threat to energy security. The main feature is that the explosion flame is initially disturbed by the coal gangue. To recognize the characteristics of
Zhenqi Liu +5 more
doaj +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
The long-term consequences of short-term responses to disturbance: Experiences from whalewatching impact assessment [PDF]
Studies often use behavioral responses to detect the impact of given disturbances on animals. However, the observation of these short-term responses can often lead to contradicting results.
Bejder, Lars +3 more
core +1 more source
Assessing conservation of a tropical African estuary : waterbird disturbance, livelihoods, and ecotourism [PDF]
The aim of this study was to evaluate the potential costs and benefits of increasing conservation in the Sabaki River Mouth Important Bird Area. This was achieved by assessing the vulnerability of waterbirds to disturbance from human activity in the ...
England, Kate
core +1 more source
[Acid-base disturbances in intensive-care patients].
Acid-base disturbances may cause a variety of symptoms, multi-organ failure and compromised immune defense. The aim of this paper is to provide an overview of acid-base disturbances in intensive-care patients.The article is based on a non-systematic search in Pub Med, a textbook on intensive care and the authors' clinical experience.The Henderson ...
Nils, Smith-Erichsen +2 more
openaire +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Embedded Model Control calls for disturbance modeling and rejection [PDF]
Robust control design is mainly devoted to guaranteeing the closed-loop stability of a model-based control law in the presence of parametric uncertainties.
Perez, C. +5 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source

