Results 61 to 70 of about 143,865 (293)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Impact of sleep disturbances on outcomes in intensive care units

Critical Care
Abstract Background Sleep deprivation is common in ICUs and may alter respiratory performance. Few studies have assessed the role of sleep disturbances on outcomes in critically ill patients. Objectives We hypothesized that sleep disturbances may be associated with poor outcomes in ICUs.
Marchasson, Laura, Rault, Christophe, Le Pape, Sylvain, Arrivé, François, Coudroy, Rémi, Frat, Jean-Pierre, Bironneau, Vanessa, Jutant, Etienne-Marie, Heraud, Quentin, Drouot, Xavier, Thille, Arnaud W.   +10 more
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Measurement of micro synthetic jet actuation using intensity of disturbance [PDF]

, 2007
Synthetic jet actuator (SJA), as a zero-net-mass but non-zero momentum device, has shown great potential in controlling laminar separation caused by adverse pressure gradient in a boundary layer flow.
Hong, G., Walker, P., Walker, P, Hong, G
core  

Seed bank dynamics of Mediterranean pastures subjected to mechanical disturbance

, 1990
Vegetation and buried germinable seeds were examined in Mediterranean pastures differing both in time elapsed since last ploughing and in intensity of disturbance. Densities of buried germinable seeds in the greenhouse were determined from 10 × 10 × 3 cm
Ortega Quero, Marta, Peco, Begoña, Levassor, Catherine   +2 more
core   +1 more source

REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity [PDF]

, 1990
Nine healthy male subjects were deprived of REM sleep during the first 5 h after sleep onset. Afterwards recovery sleep was undisturbed. During the deprivation period the non-REM EEG power spectrum was reduced when compared to baseline for the ...
Dijk, D.J.,, BEERSMA, DGM, Beersma, D.G.M., DIJK, DJ, Blok, Guus, Everhardus, I., Everhardus, I.,, Blok, C.G.H.,, Dijk, D.J., Beersma, D.G.M.,, BLOK, CGH, EVERHARDUS, I   +11 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The impact of a catastrophic storm event on benthic macroinvertebrate communities in upland headwater streams and potential implications for ecological diversity and assessment of ecological status [PDF]

, 2012
Upland headwater streams are dynamic systems, responding rapidly to changes in climatic conditions. This study examined the effects of a catastrophic rainfall event, that occured on 24 October 2011 on the east coast of Ireland, on the macroinvertebrate ...
Blacklocke, Sean, Michael Bruen, Kelly-Quinn, Mary, Feeley, Hugh, Sean Blacklocke, Stephen Davis, Mary Kelly-Quinn, Hugh B. Feeley, Bruen, Michael, Davis, Stephen, Feeley, Hugh B.   +10 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source