Results 51 to 60 of about 135,485 (258)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Robustness Analysis of Global Exponential Stability of Nonlinear Systems With Deviating Argument and Stochastic Disturbance

IEEE Access, 2017
Robust performance of nonlinear systems has attracted phenomenal worldwide attention. It is well known that deviating argument and stochastic disturbance may derail the evolution properties of nonlinear systems.
Jin-E Zhang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Disturbance intensity drives structural, compositional and diversity attributes in tropical dry forests of Central India

Trees, Forests and People
Disturbance intensity plays an important role in influencing the structural and functional dynamics of ecosystems. The present study was undertaken in the tropical dry deciduous forests of Central India under varying disturbance intensities to understand
Satendra Kumar Rathaude, Shairq Irtiqa, P.P. Abdul Rahim, Zishan Ahmad Wani, Subashree Kothandaraman, Javid Ahmad Dar   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Measurement and Analysis of Radiated Disturbance Characteristics of ±320 kV Modular Multilevel Converter System

IEEE Access, 2019
The radiated electromagnetic disturbance was evaluated by measuring the electric field intensity in a bandwidth of 10 kHz-2.75 GHz near the valve hall, direct-current (DC) area, reactor room, and transformers in a ±320-kV modular multilevel ...
Jian Zhang, Tiebing Lu, Weidong zhang, Jun Xu, Wenqi Li   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Impact of sleep disturbances on outcomes in intensive care units

Critical Care
Abstract Background Sleep deprivation is common in ICUs and may alter respiratory performance. Few studies have assessed the role of sleep disturbances on outcomes in critically ill patients. Objectives We hypothesized that sleep disturbances may be associated with poor outcomes in ICUs.
Marchasson, Laura, Rault, Christophe, Le Pape, Sylvain, Arrivé, François, Coudroy, Rémi, Frat, Jean-Pierre, Bironneau, Vanessa, Jutant, Etienne-Marie, Héraud, Quentin, Drouot, Xavier, Thille, Arnaud   +10 more
openaire   +2 more sources