Results 81 to 90 of about 135,443 (258)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Remote Sensing Assessment of Forest Disturbance across Complex Mountainous Terrain: The Pattern and Severity of Impacts of Tropical Cyclone Yasi on Australian Rainforests

Remote Sensing, 2014
Topography affects the patterns of forest disturbance produced by tropical cyclones. It determines the degree of exposure of a surface and can alter wind characteristics.
Robinson I. Negrón-Juárez, Jeffrey Q. Chambers, George C. Hurtt, Bachir Annane, Stephen Cocke, Mark Powell, Michael Stott, Stephen Goosem, Daniel J. Metcalfe, Sassan S. Saatchi   +9 more
doaj   +1 more source

WTEC: A new index to estimate the intensity of ionospheric disturbances

Results in Physics, 2018
We propose a new index, WTEC, to estimate the level of ionospheric disturbances from Global Navigation Satellite Systems (GNSS) data. The index is calculated based on dual-frequency phase measurements from single GNSS receiver. An index value exhibits the average intensity of the total electron content (TEC) variations over specified periods in the ...
S.V. Voeykov, A.S. Yasyukevich, I.K. Edemskiy, N.P. Perevalova, Yu.V. Yasyukevich   +4 more
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Factors affecting woody plant species diversity of fragmented seasonally dry oak forests in the Mixteca Alta, Oaxaca, Mexico

Revista Mexicana de Biodiversidad, 2013
We explored the relationship between fragment area, topographic heterogeneity, and disturbance intensitywith tree and shrub species diversity in seasonally dry oak forest remnants in the Mixteca Alta, Oaxaca, Mexico.
María de los Remedios Aguilar-Santelises, Rafael F. del Castillo   +1 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Contribution of seagrass plants to CO2 capture in a tropical seagrass meadow under experimental disturbance.

PLoS ONE, 2017
Coastal vegetative habitats are known to be highly productive environments with a high ability to capture and store carbon. During disturbance this important function could be compromised as plant photosynthetic capacity, biomass, and/or growth are ...
Diana Deyanova, Martin Gullström, Liberatus D Lyimo, Martin Dahl, Mariam I Hamisi, Matern S P Mtolera, Mats Björk   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Spatial and temporal dynamics of a bark beetle outbreak in the Eastern European Alps

Ecosphere
The Alps are currently considered among the ecoregions with the highest magnitude of average bark beetle disturbance per year in Europe. We present a disturbance characterization based on a unique database including more than 50,000 records of ground ...
Anna Candotti, Nuno Carvalhais, Siyuan Wang, Enrico Tomelleri   +3 more
doaj   +1 more source