Results 61 to 70 of about 1,714,874 (281)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Carbon redistribution by erosion processes in an intensively disturbed catchment [PDF]

CATENA, 2017
Peer ...
Boix-Fayos, Carolina, Martínez-Mena García, M. Dolores, Pérez-Cutillas, Pedro, de Vente, Joris, González Barberá, Gonzalo, Mosch, Wouter, Navarro-Cano, J. A., Gaspar Ferrer, Leticia, Navas Izquierdo, Ana   +8 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Enriching plant diversity in grasslands by large-scale experimental sward disturbance and seed addition along gradients of land-use intensity

, 2016
Aims The relationship between biodiversity and ecosystem functioning is among the most active areas of ecological research. Furthermore, enhancing the diversity of degraded ecosystems is a major goal in applied restoration ecology.
Klaus, Valentin H., Kleinebecker, Till, Hölzel, Norbert, Schäfer, Deborah, Prati, Daniel, Fischer, Markus   +5 more
core   +1 more source

Habitat-mediated facilitation and counteracting ecosystem engineering interactively influence ecosystem responses to disturbance [PDF]

, 2011
Recovery of an ecosystem following disturbance can be severely hampered or even shift altogether when a point disturbance exceeds a certain spatial threshold. Such scale-dependent dynamics may be caused by preemptive competition, but may also result from
Zee, Els M. van der, Zee, Els M. van der,, van der Heide, Tjisse; id_orcid, van der Heide, Tjisse, Eriksson, Britas Klemens; id_orcid, van der Heide, T., Eriksson, B.K., O'Hara, R., O'Hara, Robert, Tjisse van der Heide, Heide, Tjisse van der,, Johan S. Eklöf, Johan S Eklöf, Serena Donadi, Eklöf, Johan,, O\u27Hara, R., Robert O'Hara, Eklöf, Johan S., Heide, Tjisse van der, Els M van der Zee, Eklöf, Johan, Eklöf, J.S., O´Hara, Robert, van der Zee, Els, O’Hara, Robert,, Els M. van der Zee, Eklöf, Johan S.,, Eriksson, Britas Klemens, Donadi, Serena, Britas Klemens Eriksson, O'Hara, Robert B., van der Zee, Els M., Donadi, Serena,, van der Zee, E.M., Eriksson, Britas Klemens,, Donadi, S.   +35 more
core   +3 more sources

High species richness of sheep‐grazed sand pastures is driven by disturbance‐tolerant and weedy short‐lived species

Ecology and Evolution
We selected 15 sheep‐grazed sand pastures along a gradient of increasing grazing intensity to study the fine‐scale patterns of main biomass fractions (green biomass, litter) and that of plant species and functional groups (life forms and social behaviour
Gergely Kovacsics‐Vári, Judit Sonkoly, Katalin Tóth, Andrea McIntosh‐Buday, Patricia Elizabeth Díaz Cando, Viktória Törő‐Szijgyártó, Nóra Balogh, Luis Roberto Guallichico Suntaxi, Francis David Espinoza Ami, Gábor Matus, Béla Tóthmérész, Péter Török   +11 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

SPECIES SIMILARITY - DISTANCE RELATIONSHIP IN WETLANDS: EFFECT OF DISTURBANCE INTENSITY

, 2009
Disturbance is considered to be one of the main factors influencing variations in species diversity. While many experimental and observational studies provide a good understanding of how disturbance maintains the alpha-diversity, we know little about how
Lu, T, Fu, BJ, Zhang, YX, Ni, HW, Ma, KM, Ma, KM, Chinese Acad Sci, State Key LUrban & Reg Ecol, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China.   +5 more
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