Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System [PDF]
International Journal of NanomedicineWeiran Ma,1,2 Xiaoying Wang,2 Dongqi Zhang,3 Xupeng Mu1 1Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, People’s Republic of China; 2Jilin University School of Pharmaceutical Sciences, Changchun, 130021 ...
Weiran Ma, Xiaoying Wang, Xupeng Mu
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Crystallographic Studies Evidencing the High Energy Tolerance to Disrupting the Interface Disulfide Bond of Thioredoxin 1 from White Leg Shrimp Litopenaeus vannamei [PDF]
Molecules, 2014 Thioredoxin (Trx) is a small 12-kDa redox protein that catalyzes the reduction of disulfide bonds in proteins from different biological systems. A recent study of the crystal structure of white leg shrimp thioredoxin 1 from Litopenaeus vannamei (LvTrx ...
Adam A. Campos-Acevedo +1 more
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Structural and Catalytic Roles of the Disulfide Bonds Cys19–Cys154 and Cys134–Cys199 in Trypsin-like Proteases: Evolutionary Insights for Disulfide Bond Acquisition [PDF]
MoleculesTrypsin is one of the most extensively studied enzymes in biochemistry. However, little information is available on the role of the disulfide bonds to establish the correct conformation and enzyme activity during molecular evolution.
Maiko Minakata +9 more
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FEBS Open Bio, 2014 Protein disulfide isomerases (PDIs), a family of thiol-disulfide oxidoreductases that are ubiquitous in all eukaryotes, are the principal catalysts for disulfide bond formation. Here, we investigated three rice (Oryza sativa) PDI family members (PDIL1;1,
Yayoi Onda
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In Silico Modeling of Myelin Oligodendrocyte Glycoprotein Disulfide Bond Reduction by Phosphine-Borane Complexes [PDF]
PharmaceuticalsBackground: Neurodegenerative diseases can cause vision loss by damaging retinal ganglion cells in the optic nerve. Novel phosphine-borane compounds (PBs) can protect these cells from oxidative stress via the reduction of disulfide bonds.
Raheem Remtulla +2 more
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Validation of the Intermolecular Disulfide Bond in Caspase-2 [PDF]
BiologyCaspases are a family of proteins involved in cell death. Although several caspase members have been well characterized, caspase-2 remains enigmatic. Caspase-2 has been implicated in several phenotypes, but there has been no consensus in the field about ...
Megan E. Amason +4 more
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Stability and functional consequences of disulfide bond engineering in Aspergillus flavus uricase [PDF]
Scientific ReportsDisulfide bond engineering is a promising strategy for enhancing the stability and functional lifespan of enzymes in therapeutic and industrial applications.
Mohammad Reza Rahbar +6 more
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QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma [PDF]
Advanced ScienceDisulfide bond modification is critical in maintaining protein structure and activity, but its roles in regulating tumor stemness and chemoresistance remain underexplored.
Wo‐Ming Chen +12 more
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Analysis of Disulfide Bond Formation [PDF]
Current Protocols in Protein Science, 2017 AbstractIn this unit, protocols are provided for detection of disulfide bond formation in cultures of intact cells and in an in vitro translation system containing isolated microsomes or semi‐permeabilized cells. First, the newly synthesized protein of interest is biosynthetically labeled with radioactive amino acids in a short pulse.
Braakman, Ineke +3 more
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The name's bond……disulfide bond [PDF]
Current Opinion in Structural Biology, 2007 A repeating theme in the structural biology of disulfide oxidants and isomerases is the extraordinary architectural similarity between functionally related proteins from prokaryotes and eukaryotes. The recently determined structure of full-length yeast protein disulfide isomerase (PDI) reveals a U-shaped molecule with two redox-active sites. It bears a
Heras, Begona +3 more
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