Results 181 to 190 of about 179,181 (346)

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

DiPTH-Cystine and PTH-Cysteine in Disulfide Bond Analysis Using Automated Edman Degradation. [PDF]

J Pept Sci
Kühl T, Elsayed YY, Terekhov A, Imhof D.   +3 more
europepmc   +1 more source

Mutants in disulfide bond formation that disrupt flagellar assembly in Escherichia coli.

, 1993
Frank E. Dailey, Howard C. Berg
openalex   +1 more source

Simple, Automated, High Resolution Mass Spectrometry Method to Determine the Disulfide Bond and Glycosylation Patterns of a Complex Protein [PDF]

, 2011
Gennett M. Pike, Benjamin J. Madden, Deborah C. Melder, M. Cristine Charlesworth, Mark J. Federspiel   +4 more
openalex   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Sulfur-Dependent Disulfide Bond Disruption in Insulin Resistance: A Hypothesis. [PDF]

Adv Pharm Bull
Akl MM, Ahmed A.
europepmc   +1 more source

Deamidation and Disulfide Bonding in Human Lens γ-Crystallins

, 1998
Stacy R.A. Hanson, David L. Smith, Jean B. Smith   +2 more
openalex   +1 more source

Corrigendum: Disulfide Bond Cleavage: A Redox Reaction Without Electron Transfer [PDF]

, 2011
F.R. Hofbauer, Irmgard Frank
openalex   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

New insights on the disulfide bond status in soy proteins from mass spectrometry-pLink2 analysis and molecular docking

Longzheng Zhou, Xiaoxiao Feng, Xiangzhen Kong, Dawei Li, Yeming Chen, Caimeng Zhang, Yufei Hua   +6 more
openalex   +1 more source