Results 201 to 210 of about 179,181 (346)

The conserved disulfide bond of human tear lipocalin modulates conformation and lipid binding in a ligand selective manner

, 2011
Oktay K. Gasymov, Adil R. Abduragimov, Ben J. Glasgow   +2 more
openalex   +2 more sources

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

Reaction of N-chloro formimidoyl chlorides with disulfides [PDF]

, 1974
Geevers, J., Trompen, W.P.
core   +2 more sources

Pathological Disulfide Bond Crosslinking: Molecular Insights into Amyloidogenesis and Diseases Progression. [PDF]

Chembiochem
Kang DM, Lukianenko N, Baik JH, Kim YK, Lim S.   +4 more
europepmc   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity. [PDF]

Nat Commun
Qin W, Li R, Liu J, Liu J, Wang X, Hu B, Zheng Z, Yu Z, Li G.   +8 more
europepmc   +1 more source

Disulfide Bond-Based SN38 Prodrug Nanoassemblies with High Drug Loading and Reduction-Triggered Drug Release for Pancreatic Cancer Therapy

, 2023
Zhi-Xin Zhong, Xu‐zhao Li, Jintao Liu, Nan Qin, Hong‐Quan Duan, Xiao-Chuan Duan   +5 more
openalex   +2 more sources

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Systematic determination of disulfide bond reduction potentials reveals a nonequilibrium redox hierarchy in cyanobacteria [PDF]

Kenya Tanaka, Akihiko Kondo, Tomohisa Hasunuma   +2 more
openalex   +1 more source

Heparin enhances protamine disulfide bond reduction during in vitro decondensation of human spermatozoa [PDF]

, 2012
Vanina Laura Julianelli, B. Farrando, C. Alvarez Sedó, Lucrecia Calvo, Marina Romanato, Juan Carlos Calvo   +5 more
openalex   +1 more source