Results 241 to 250 of about 179,181 (346)
Polysulfides promote protein disulfide bond formation in microorganisms growing under anaerobic conditions. [PDF]
Xin Y +6 more
europepmc +1 more source
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng +13 more
wiley +1 more source
Disulfide Bond Engineering of Soluble ACE2 for Thermal Stability Enhancement. [PDF]
Kim YS, Kim M, Park HM, Kim HJ, Ryu SE.
europepmc +1 more source
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang +9 more
wiley +1 more source
ConoGPT: Fine-Tuning a Protein Language Model by Incorporating Disulfide Bond Information for Conotoxin Sequence Generation. [PDF]
Zhao G, Ge C, Han W, Yu R, Liu H.
europepmc +1 more source
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang +9 more
wiley +1 more source

