Results 81 to 90 of about 21,898 (241)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Diterpenoid alkaloids from Delphinium davisii

, 1996
Three new hetisane-type diterpenoid alkaloids, davisinol (6), 18-benzoyldavisinol (7), and Davisin (9) have been isolated from Delphinium davisii Munz. and their structures established by detailed spectroscopic studies.
Pelletier, SW, Desai, HK, Srivastava, SK, Mericli, AH, Ilarslan, R, Park, JC, Mericli, F, Hart, BP, Ulubelen, A, Joshi, BS   +9 more
core   +2 more sources

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

A new ent-labdane diterpenoid from Andrographis paniculata

, 2010
A new ent-labdane diterpenoid, 19-O-beta-D-glucopyranosyl-ent-labda-8(17),13-dien-15,16,19-triol, together with six known ent-labdane diterpenoids, was isolated from the aerial parts of Andrographis paniculata.
Peng, Shu Lin, Ding, LS, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China, Deng, Wen Long, Dan, Chun, Li, Na, Ding, Li Sheng, Zou, Qiong Yu   +6 more
core  

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

Clerodane diterpenoids with anti-inflammatory activity from the tuberous root of Paratinospora sagittata (Oliv.) Wei Wang

Frontiers in Pharmacology
Seven novel clerodane diterpenoids, designated tinotanoids I–O (1−7), were isolated from the tuberous roots of Paratinospora sagittata (Oliv.) Wei Wang [syn.: Tinospora sagittata var. yunnanensis (S.Y.Hu) H.S.Lo; Menispermaceae].
Hailin Li, Jing Liu, Chuhong Fang, Shanglei Ning   +3 more
doaj   +1 more source

SynThesis of C1-substituted analogues of diterpenoid alkaloids

, 2010
Full text is available to authenticated members of The University of Auckland only.Plants of the Delphinium and Aconitum genera, the active constituents of which are diterpenoid alkaloids, have long been known in herbal medicine.
Goodall, Kirsten Julie
core  

A marine verticillane diterpenoid from Cespitularia erecta

, 2008
The dichloromethane extract of Cespitularia erecta afforded a new verticillane diterpenoid (1) and sarcophytol A (2) by silica gel chromatography.
Bowden, Bruce F., Janairo, Gerado C., Janairo, Gerardo C., Janairo, Jaime Raul O., Ragasa, Consolacion Y.   +4 more
core   +1 more source

Synergistic enhancement SPF from annatto seed oil and alkaline extracts in association with organic UV filters

International Journal of Cosmetic Science, EarlyView.
An SPF formulation incorporating Bixa orellana seed extracts and oils showed enhanced UV protection, highlighting the potential of natural bioactive compounds as effective boosters in photoprotective cosmetic products. Abstract Objective This study investigated the antioxidant activity of oil and alkaline aqueous extracts obtained from Bixa orellana ...
Ister Cordeiro Mariotini, Aliny Rodrigues de Jesus da Conceição, Rodrigo Rezende Kitagawa, Bernardo de Jesus Pavuna, Claudia Masrouah Jamal, Claudineia Aparecida Sales de Oliveira Pinto, André Rolim Baby, Fabiana Vieira Lima Solino Pessoa, Mariana Santos Pinheiro   +8 more
wiley   +1 more source

In silico exploring the mechanisms of action of diterpenoids from Rabdosia serra against lung cancer through inhibition of the anti-apoptotic pathway

Research Results in Pharmacology
Introduction: Apoptosis resistance in non-small cell lung cancer is frequently sustained by pro-survival Bcl-2 family proteins such as Mcl-1, motivating the search for new Mcl-1 inhibitors from natural products, including diterpenoids from Rabdosia serra.
Hung Duc Nguyen
doaj   +1 more source