Results 241 to 250 of about 2,501,958 (326)

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Glycyrrhiza Protein-Based Nanoparticles Enhance the Oral Bioavailability and Analgesic Efficacy of Paeoniflorin. [PDF]

Int J Nanomedicine
Yang X, Guo Q, Dong Y, Wang H, Dang M, Sun Y, Gao Y, Bai D.   +7 more
europepmc   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Chemoproteomics-based profiling elucidates the antimalarial effects of amodiaquine through disruption of glycolysis process in Plasmodium falciparum. [PDF]

Cell Commun Signal
Wang J, Wang C, Zhuge R, Tang H, Xia F, Zhang Y, Zhang J, Liu C, Wu J, Chen X, Gao P, Wang J.   +11 more
europepmc   +1 more source

The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione

The FEBS Journal, EarlyView.
12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper, Ruben Schwarz, Lara Vogelsang, Jens Sproß, Armağan Kaya, Maike Bittmann, Harald Gröger, Andrea Viehhauser, Karl‐Josef Dietz   +8 more
wiley   +1 more source

A Broad-Spectrum Copper Oxidase Synthesizes Fungal Peptidomelanin. [PDF]

ACS Omega
Srivatsan S, Pramanik S, Pradeep P, Sarkar S, Chandrappa SP, Gall R, Singh A, Chamraj B, Kasala B, Majumder U, Meenakshi TB, Reddy L, Suranse V, Arer V, Jays J, Chakravortty D, Nagarajan D.   +16 more
europepmc   +1 more source

Supplementary material to "A method for measuring total aerosol oxidative potential (OP) with the dithiothreitol (DTT) assay and comparisons between an urban and roadside site of water-soluble and total OP"

, 2017
Dong Gao, Ting Fang, Vishal Verma, Linghan Zeng, Rodney Weber   +4 more
openaire   +1 more source

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source

Development of Cell-Derived Plasma Membrane Vesicles as a Nanoparticle Encapsulation and Delivery System. [PDF]

Cell Mol Bioeng
Kheradmandi M, Farnoud AM, Burdick MM.
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source