Results 61 to 70 of about 110,008 (267)

Composition, Chemical Variability, and Anti‐inflammatory Activity of the Berry Essential Oil of Juniperus phoenicea L. var. Turbinata From Algeria

Chemistry &Biodiversity, EarlyView.
ABSTRACT The chemical composition of 66 oil samples isolated from the berries of individual trees of Juniperus phoenicea var. turbinata, collected in six locations from Algeria, was investigated by gas chromatography with flame ionization detection, gas chromatography‐mass spectrometry, and 13C‐nuclear magnetic resonance.
Chérifa Yassamine Osmani, Chahrazed Bekhechi, Charaf Eddine Watheq Malti, Haciba Meziane, Joseph Casanova, Mathieu Paoli, Félix Tomi   +6 more
wiley   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

Chemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo, Rita de Cássia Vilhena da Silva, Valdir Cechinel Filho, Priscila de Souza   +3 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

SYNTHESIS AND DIURETIC ACTIVITY OF 2-(5-(PHENOXYMETHYL)-4-R1-1,2,4-TRIAZOLE-3-YLTHIO)ACETIC ACIDS AND THEIR SALTS

Zaporožskij Medicinskij Žurnal, 2014
It is known that drugs based on the 1,2,4-triazole have a wide spectrum of biological activities. They are effective cardioprotectors, hepatoprotectors, anti-oxidants, which are widely used in cardiology practice.
Yu. N. Kucheryavyi, A. G. Kaplaushenko, E. S. Pruhlo   +2 more
doaj   +1 more source

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for NAT2 Genotype and Hydralazine Therapy

Clinical Pharmacology &Therapeutics, EarlyView.
Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N‐acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as “slow acetylators”) are predicted to have increased plasma hydralazine concentrations compared with ...
Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper‐DeHoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A.G. Agúndez   +18 more
wiley   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Hoarding Symptoms in Eating Disorders: An Observational Cross‐Sectional Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Hoarding behaviors have been reported in eating disorders (EDs), particularly those characterized by binge eating; however, research on this comorbidity is scarce. This cross‐sectional observational study investigated hoarding symptoms in a community‐based sample of individuals with lifetime ED diagnoses (N = 5927).
Avantika Kapadia, Laura M. Thornton, Cynthia M. Bulik, Hunna J. Watson   +3 more
wiley   +1 more source

Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist

Medical Sciences, 2019
Kappa-opioid agonists (KOAs) enhance cardiac performance, as well as reduce infarct size and prevent deleterious cardiac remodeling following myocardial infarction.
Tyler C. Beck, Matthew A. Hapstack, Gautam S. Ghatnekar, Thomas A. Dix   +3 more
doaj   +1 more source

Adverse Childhood Experiences and Disordered Eating Behaviors Among US Children: Untangling the Developmental Sex Differences

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examined associations between adverse childhood experiences (ACEs) and heterogeneous disordered eating behaviors (DEBs) in a nationally representative sample of US children, investigating how sex and developmental stage jointly moderate these relationships.
Zékai Lu
wiley   +1 more source