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Pharmacology of Diuretics

The American Journal of the Medical Sciences, 2000
The diuretics in our therapeutic armamentarium have predictable effects based on their nephron sites of action. All but spironolactone must reach the lumen or urinary side of the nephron to exert their effects. Thus, in settings of decreased renal function, doses must be increased to deliver more diuretic into the urine.
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Use of diuretics

1994
Strictly, diuresis is increased urine flow and diuretics are substances which elicit diuresis. By this definition, water is a diuretic. In medicine, however, ‘diuretic’ has come to have a more specific meaning. In the kidney, water reabsorption is dependent primarily on Na+ reabsorption and the term diuretic is generally used to mean an agent which ...
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Diuretics

2015
This is an updated comprehensive review of the adverse effects of diuretics for the year 2015. This review includes five different groups of diuretics: carbonic anhydrase inhibitors (CAI) with a primary focus on acetazolamide as the only current CAI still used for its diuretic effect.
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Resistance to diuretics

The Clinical Investigator, 1994
Diuretics act by decreasing sodium reabsorption via inhibition of the entry of luminal sodium into the tubular cell. The various nephron segments have different mechanisms of sodium entry, and it is this characteristic that determines the site at which the diuretic acts.
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Diuretics in Hypertension

Journal of Hypertension, 1987
Thiazide diuretics have been the 'mainstay' of antihypertensive therapy for three decades. They reduce arterial pressure, initially through a fall in plasma volume and cardiac output. However, in time, output returns towards pretreatment levels, thereby accounting for a long-term fall in pressure through decreased vascular resistance.
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Diuretics

2002
ABETE, PASQUALE   +7 more
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Diuretics

2010
George M. Brenner, Craig W. Stevens
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Diuretics.

The Journal of the Maine Medical Association, 1975
The use of diuretics to treat edema is reviewed. Normal salt and water metabolism is reviewed briefly. The drugs covered are the thiazide diuretics, loop diuretics(ethacrynic acid and furosemide) and distal blocking agents (spironolactone and triamterene).
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