Results 111 to 120 of about 66,898 (267)
Advanced Science, EarlyView.This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim +10 more
wiley +1 more source
San Francisco Estuary and Watershed Science, 2007 We use selected monitoring data to illustrate how localized water diversions from seasonal barriers, gate operations, and export pumps alter water quality across the Sacramento-San Joaquin Delta (California).
Nancy E. Monsen +2 more
doaj
Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China
Advanced Science, EarlyView.This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang +3 more
wiley +1 more source
Advanced Science, EarlyView.ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang +15 more
wiley +1 more source
Advanced Science, EarlyView.CO2 reduction in pure water is enabled by a rapid‐transport fixed‐charge interface that couples nanochannels with a cationic microenvironment. This design eliminates the mass transport plateau, stabilizes key reaction intermediates, and suppresses the hydrogen evolution reaction, ultimately achieving ampere‐level current densities and stable operation ...
Qiqi Wan +8 more
wiley +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Primary repair versus diversion in penetrating colon injuries
مجله كليه طب الكندي, 2013 Back ground: In Iraq, after 2003 had more accidents of the shell, bullet and stab abdominal wounds, more over colon injuries. Objective: The aim of this study is to evaluate the most appropriate management of penetrating colon injuries, comparing the ...
Adil Karim Alhamdani +3 more
doaj
Advanced Science, EarlyView.An atomically dispersed Co–N4 single‐atom catalyst rapidly activates peroxymonosulfate to remove the antibiotic sulfamethoxazole from water. Common ions have little impact, but chloride dramatically speeds degradation by promoting a high‐valent Co(IV) = O oxidant via in situ HOCl–catalyst electron transfer.
Anting Ding +6 more
wiley +1 more source
Advanced Science, EarlyView.In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu +16 more
wiley +1 more source
Advanced Science, EarlyView.A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che +9 more
wiley +1 more source