Results 101 to 110 of about 6,654,400 (432)

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

The Double-Edged Sword of Diversity: How Diversity, Conflict, and Psychological Safety Impact Software Teams [PDF]

arXiv, 2023
Team diversity can be seen as a double-edged sword. It brings additional cognitive resources to teams at the risk of increased conflict. Few studies have investigated how different types of diversity impact software teams. This study views diversity through the lens of the categorization-elaboration model (CEM). We investigated how diversity in gender,
arxiv  

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Tropical rainforests: Diversity begets diversity [PDF]

Current Biology, 1997
Tropical rainforests exhibit an extraordinarily high level of biological diversity. A new study shows that the patterns of seedling survival surrounding parent trees are responsible in large part for this amazing diversity.
Audrey L. Mayer, Stuart L. Pimm
openaire   +3 more sources

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

New descriptions of the larval and pupal stages of Orthocladius nitidoscutellatus and Psectrocladius nevalis from Xizang, China (Diptera, Chironomidae) [PDF]

Biodiversity Data Journal
Tibetan Plateau is one of the most typical areas of biodiversity in the world because of its unique environmental and regional units, which breed unique biological communities and concentrate on many unique and rare wild animals and plants.
Xinyu Ge, Chengyan Wang, Wenxuan Pei, Yaning Tang, Wenbin Liu, Chuncai Yan   +5 more
doaj   +3 more sources

Microbial diversity in the deep sea and the underexplored “rare biosphere”

Proceedings of the National Academy of Sciences of the United States of America, 2006
The evolution of marine microbes over billions of years predicts that the composition of microbial communities should be much greater than the published estimates of a few thousand distinct kinds of microbes per liter of seawater. By adopting a massively
M. Sogin, H. Morrison, J. Huber, D. Welch, Susan M. Huse, Phillip R. Neal, J. Arrieta, G. Herndl   +7 more
semanticscholar   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Medical student diversity and the importance of advocacy in choice of career path

Discover Education
Background Medical student demographics have shifted over time, requiring medical schools to engage prospective students from diverse backgrounds.
Megan Pasquantonio-Pierce, Jessica St. Louis, Emorcia Hill, Amitai S. Miller, Joan Y. Reede, Jeffrey N. Katz   +5 more
doaj   +1 more source

Diversity & Inclusion Update - Fall 2016

, 2016
This Fall 2016 newsletter discusses ongoing campus initiatives to facilitate diversity and inclusion efforts on campus. Topics discussed include continued changes inspired by the January 2016 Town Hall meeting, such as the restructuring of the Office of ...
Office of Diversity & Inclusion,
core