Results 141 to 150 of about 1,455,942 (268)

Forest Heterogeneity by Chain Saw: How Between-Patch Variation in Old Growth Attributes Changes the Metacommunities of Beetles. [PDF]

Ecol Lett
Mitesser O, Cadotte MW, Mori AS, van der Plas F, Chao A, Rothacher J, Bässler C, Bevanda M, Biedermann PHW, Bradler P, Castañeda-Gómez A, Decker O, Delory BM, Dittrich S, Feldhaar H, Fichtner A, Kreis A, Köstler-Albert L, Lettenmaier L, von Oheimb G, Pflumm L, Pierick K, Schwalb-Willmann J, Thorn S, Vogelfänger L, Weisser W, Wegmann M, Wild C, Müller J.   +28 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Mammal defaunation leads to biotic homogenization of plant communities in tropical rainforests. [PDF]

Ecology
Ribas LGDS, Villar N, Zipparro V, Nazareth S, Souza Y, Brocardo CR, Schmaedecke G, Hortenci L, Alves RSC, Galetti M.   +9 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impact of Fire and Heat Stress on Soil Microorganisms: A Review of Community Changes, Molecular Responses and Plant-Beneficial Roles. [PDF]

Environ Microbiol Rep
Orozco-Mosqueda MDC, Flores-Piña A, Kumar A, Parra-Cota FI, de Los Santos-Villalobos S, Mitra D, Babalola OO, Santoyo G.   +7 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of Commitment to Equity, Diversity, and Inclusion on Canadian Plastic Surgery Residency Program Websites. [PDF]

Plast Surg (Oakv)
Majeed M, Shamoun V, Valiquette CR, Dengler J, Snell L.   +4 more
europepmc   +1 more source

Diversity Matters

Journal of the American College of Cardiology, 2017
Pamela S, Douglas, Kim Allan, Williams, Mary Norine, Walsh   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Beyond Ubiquity: Scale-dependent patterns of tardigrade diversity on the Iztaccíhuatl volcano. [PDF]

PLoS One
Dueñas-Cedillo A, Armendáriz-Toledano F, Cancino-López RJ, García-Román J, Ruiz EA.   +4 more
europepmc   +1 more source