Results 291 to 300 of about 5,990,883 (357)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Intercropping between persimmon and apple enriched the leaf endophytes and rhizosphere communities against apple root rot. [PDF]

BMC Plant Biol
Cun H, He P, Ahmed A, He P, Wu Y, Jiang Y, Zhang H, Tang G, Kong B, Youssef SA, Munir S, He Y.   +11 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Low genetic diversity of Aedes albopictus (Diptera: Culicidae) in El Salvador based on mitochondrial COI sequences: evidence of a well-preserved ancestral lineage in the Americas. [PDF]

J Insect Sci
Palomo JL, Rogel JI, Moreno MA, Joyce AL.   +3 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

The modern expansion of Dscam1 isoform diversity in Drosophila is linked to fitness and immunity. [PDF]

PLoS Biol
Dong H, Wu L, Wang Z, Qu H, Xie J, Liu Y, Lv J, Bao N, Zhang J, Guo P, Yan R, Fu J, Shi J, Fu Y, Li L, Du Y, Ma H, Shi F, Huang J, Jin Y.   +19 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Effect of canal blocking on biodiversity of degraded peatlands: Insight from West Kalimantan. [PDF]

PLoS One
Imron MA, Rachmawati FD, Dewi T, Albihad D, Simanullang GMI, Poor EE.   +5 more
europepmc   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

FEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

The golden jackal (Canis aureus): interaction of fur and fecal microbiota, host genetics and animal traits. [PDF]

Anim Microbiome
Lapid R, Motro Y, Juravel K, King R, Moran-Gilad J, Kahila Bar-Gal G.   +5 more
europepmc   +1 more source