Results 61 to 70 of about 1,812,907 (295)

Statistical inference of the generation probability of T-cell receptors from sequence repertoires

, 2012
Stochastic rearrangement of germline DNA by VDJ recombination is at the origin of immune system diversity. This process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and ...
A. M. Walczak, A. Murugan, Arstila, Blum, C. G. Callan, Cabaniols, Gauss, Lafaille, Lieber, Lieber, Mason, Monod, Robins, Schatz, T. Mora, Venturi, Verkaik, Wang, Weinstein   +18 more
core   +1 more source

Somatic Generation of Immune Diversity

Scandinavian Journal of Immunology, 1988
One day in the fall of 1970, I received an airmail letter from Renato Dulbecco who was traveling in Europe. At that time I was a postdoctoral fellow in his laboratory at the Salk Institute. The letter, written on stationery of the Hotel Hassler in Rome, said:
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Semantic-Aware 3D GAN: CLIP-Guided Disentanglement for Efficient Cross-Category Shape Generation

Applied Sciences
Generative Adversarial Networks (GANs) have achieved remarkable success in image generation. Although GAN-based approaches have also advanced three-dimensional (3D) data synthesis, they exhibit stagnation when compared to other state-of-the-art 3D ...
Weinan Cai, Zongji Wang, Yuanben Zhang, Zhihong Zeng, Xinming Li, Junyi Liu   +5 more
doaj   +1 more source

Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]

, 2018
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S., Barner-Kowollik, Christopher, Becer, C. Remzi, Collis, Dominic, Edwards-Gayle, Charlotte J. C., Hamley, Ian W., Hartweg, Manuel, Kaupp, Michael, Radvar, Elham, Rambo, Robert, Reza, Mehedi, Ruokolainen, Janne, Steinkoenig, Jan   +12 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Changes in the Population Genetic Structure of Captive Forest Musk Deer (Moschus berezovskii) with the Increasing Number of Generation under Closed Breeding Conditions

Animals, 2020
We investigated the genetic diversity of the population of captive forest musk deer (Moschus berezovskii) in Barkam Musk Deer Breeding Centre using twelve microsatellite markers, and then analyzed the change in genetic structure of successive generation ...
Yonghua Cai, Jiandong Yang, Jianming Wang, Ying Yang, Wenlong Fu, Chengli Zheng, Jianguo Cheng, Yutian Zeng, Yan Zhang, Ling Xu, Yan Ren, Chuanzhi Lu, Ming Zhang   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genetic diversity of Lusitano horse in Brazil using pedigree information [PDF]

, 2018
This study aimed to evaluate population parameters and to describe the genetic diversity of the Lusitano breed in Brazil using pedigree data. Two populations were evaluated: total population (TP) containing 18,922 animals, and reference population (RP)
Chardulo, L. A. L., Curi, R., Faria, R. S., Maiorano, A., Santos, R., Silva, J. A., Vicente, António   +6 more
core