Results 61 to 70 of about 36,225 (338)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

RGG-PSO+: Random Geometric Graphs Based Particle Swarm Optimization Method for UAV Path Planning

International Journal of Computational Intelligence Systems
Evolutionary algorithms, such as particle swarm optimization (PSO), are widely applied to UAV path planning problems. However, the fixed particle length of PSO, which may not be suitable for the scenario, will compromise the search efficiency. This paper
Yang Liu, Xiaomin Zhu, Xiao-Yi Zhang, Jiannan Xiao, Xiaohan Yu   +4 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

A Divide and Conquer Algorithm for Exploiting Policy Function Monotonicity [PDF]

SSRN Electronic Journal, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Grey Gordon, Shi Qiu
openalex   +4 more sources

Investigation of Energy and Power Characteristics of Various Matrix Multiplication Algorithms

Energies
This work studied the energy behavior of six matrix multiplication algorithms with various physical asset usage patterns. Two were variants of the straight inner product of rows and columns. The rest were variants of Strassen’s divide-and-conquer.
Salem Alsari, Muhammad Al-Hashimi
doaj   +1 more source

Reducing Computational Overhead by Improving the CRI and IRI Implication Step

Journal of Control Science and Engineering, 2015
In conventional SISO fuzzy expert systems (n-element input, m-element output), the implication step requires the O(n×m) operations using compositional rule-based inference (CRI) and individual rule-based inference (IRI).
Thoai Phu Vo, Joy Iong-Zong Chen
doaj   +1 more source

A Novel Approach to Distributed Multi-Class SVM

, 2014
With data sizes constantly expanding, and with classical machine learning algorithms that analyze such data requiring larger and larger amounts of computation time and storage space, the need to distribute computation and memory requirements among ...
Govada, Aruna, Ranjani, Shree, Sahay, S. K., Viswanathan, Aditi   +3 more
core   +1 more source

A Divide-and-Conquer Algorithm for Betweenness Centrality [PDF]

Proceedings of the 2015 SIAM International Conference on Data Mining, 2015
The problem of efficiently computing the betweenness centrality of nodes has been researched extensively. To date, the best known exact and centralized algorithm for this task is an algorithm proposed in 2001 by Brandes. The contribution of our paper is Brandes++, an algorithm for exact efficient computation of betweenness centrality.
Erdos, Dora, Ishakian, Vatche, Bestavros, Azer, Terzi, Evimaria   +3 more
openaire   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source