Results 51 to 60 of about 4,687,854 (255)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
International Journal of Technology, 2017 The objective of this study was to compare the impacts of financing investment scenarios on piped-natural GPs for households in Indonesia using government, business entity, and mixed investment scenarios.
Aji Agraning Bawono, Eny Kusrini
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Central European Journal of Public Policy, 2014 Empirical studies in decentralized settings associate ambiguities in the division of responsibilities between government spheres with coordination problems. This study explores the mechanisms behind this association, mainly drawing on in-depth interviews
Hans Dubois
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
OTONOMI DAERAH DALAM PERSEPEKTIF PEMBAGIAN URUSAN PEMERINTAH-PEMERINTAH DAERAH DAN KEUANGAN DAERAH
Fiat Justisia, 2015 Framework of the Unitary Republic of Indonesia of the concepts embodied in the provisions of Article 18 paragraph (1) of the Constitution of the Republic of Indonesia in 1945, the Republic of Indonesia is divided into provincial regions and districts are
Fatkhul muin
doaj
Analysis of KPBU Policy in Using Islamic Financial Instruments in Indonesia
Indonesian Interdisciplinary Journal of Sharia EconomicsThe investment target for fulfillment related to infrastructure problems reaches Rp 6445 trillion, Islamic finance focuses on risk sharing, and money management in successful groups.
Wening Pamulatsih, Mitra Sami Gultom
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Policy making in divided government. A pivotal actors model with party discipline [PDF]
This article presents a formal model of policy decision-making in an institutional framework of separation of powers in which the main actors are pivotal political parties with voting discipline. The basic model previously developed from pivotal politics
Josep M. Colomer
core