Results 71 to 80 of about 57,185 (292)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Soulmates in The Quran and Prophetic Tradition [PDF]

, 2017
Just like letters that go together in a word, there are soulmates who came in the symbolic “Be.” Spiritual partnership found in soulmates are far from foreign to Islam: to the contrary The Quran and Prophetic Tradition are replete with them. The need for
Miller, Maryam
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Theology of Decision-making and Artificial Intelligence [PDF]

Вестник Православного Свято-Тихоновского гуманитарного университета: Серия I. Богословие, философия
The article studies the phenomenon of decision-making by humans and by artificial intelligence in the context of the Orthodox theology of person on the one hand and of the theology of knowledge on the other.
Methody Zinkovskiy
doaj   +1 more source

DIVINE AGENCY AND THE PRINCIPLE OF THE CONSERVATION OF ENERGY

Zygon: Journal of Religion and Science, 2009
Many contemporary thinkers seeking to integrate theistic belief and scientific thought reject what they regard as two extremes. They disavow deism in which God is understood simply to uphold the existence of the physical universe, and they exclude any view of divine influence that suggests the performance of physical work through an immaterial cause ...
openaire   +1 more source

The Misunderstanding between Schizophrenia and Clairaudience [PDF]

, 2018
This research focuses on Schizophrenia and Clairaudience that is part of doctoral research for a Doctorate of Metaphysical Sciences at the University of Metaphysics. The mental illness known as Schizophrenia has been known for centuries.
Richardson, Philippa Sue
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

THE MORAL FOUNDATION OF THE RELIGIOUS AND PHILOSOPHICAL CURRENTS OF RUSSIAN COSMISM (THE TEACHINGS OF V. SOLOVYOV)

Научный вестник МГТУ ГА, 2016
In this article, the authors considered the religious - philosophical component of Russian cosmism, its moral Foundation. A brief philosophical analysis of the problem of good and evil in the teaching of one of the representatives of religious branches ...
N. A. Nekrasova, A. G. Soshnina
doaj  

Using the Stars to Indigenize the Public Sphere: Matariki over New Zealand

Religions, 2019
As the rate of affiliation to Christian identity continues to decline in Aotearoa New Zealand (only 49 percent of the population said they were Christian in the last census), public space has become more receptive to other forms of religiosity.
Ann Hardy, Hēmi Whaanga
doaj   +1 more source