Results 211 to 220 of about 223,708 (309)

WHO declares Mpox a public health emergency: "you haven't closed borders with Africa, the epicenter?"-YouTube reactions highlight geopolitical tensions. [PDF]

Ther Adv Infect Dis
Pitua I, Bongomin F.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Decolonising against a backdrop of colonial amnesia: barriers, challenges, and finding a way forward. [PDF]

Front Sociol
Shah JK.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Knowledge, attitudes and factors associated with the awareness of caregivers of under-five children regarding the malaria vaccine in the Tiko Health District, Cameroon: A community-based cross-sectional study. [PDF]

PLOS Glob Public Health
Idang MA, Nsobinenyui D, Ukah CE, Yunika LK, Ngu CN, Fuanghene Wefuan R, Dang SZ, Ndip NE, Feguem MP, Shei CM, Nsagha DS.   +10 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Trends and factors associated with pneumonia mortality at Buea Regional Hospital in Cameroon from 2020 to 2023. [PDF]

PLoS One
Tufon KA, Foumene TP, Esembeson M, Bolimo AF, Yemene TP, Nguatem CM, Georges TD, Gobina RM, Cyrille N, Munge T, Mokake NDM.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Guidelines for Caring for Incapacitated Teachers and Students at Former Jesuit Colleges in Europe. [PDF]

J Relig Health
Kochanowicz J, Topij-Stempińska B, Paal P.   +2 more
europepmc   +1 more source

Spiritual Violence, Gender, and Sexuality: Implications for Seeking and Dwelling Among Some Catholic Women and LGBT Catholics [PDF]

, 2016
Tobin, Theresa
core   +1 more source