Results 31 to 40 of about 188,691 (247)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Sacristy of the Virgin of the Basílica del Pilar: Breviary of Marian Apology

Religions
This article analyses the iconographic cycle of the Sacristy of the Virgin in the Basílica del Pilar, with the aim of unveiling the complex system of visual symbols present in its bas-reliefs.
Esther Ortiz
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Foederis Arca—The Ark of the Covenant, a Biblical Symbol of the Virgin Mary

Religions
This article attempts to document why the Virgin Mary is symbolically designated by the biblical figure “Ark of the Covenant” (Foederis Arca), as reflected in one of the invocations of the Litany of Loreto (Litaniae Lauretanae).
José María Salvador-González
doaj   +1 more source

"Sicut lilium inter spinas". Floral Metaphors in Late Medieval Marian Iconography from Patristic and Theological Sources

Eikón Imago, 2014
This paper proposes  an  interpretation  of the  flowers  and  other plant motifs present in some late medieval images of four Marian themes: the Virgin Enthroned with Child, the Virgin of Humility, the Sacra Conversazione and the Coronation of the ...
José María Salvador González
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Subverting “Divine” Bengali Motherhood in Rituparno Ghosh’s Film Titli (2002) [PDF]

Rituparno Ghosh is one of the most prolific filmmakers from Bengal, whose narrative depiction gained global critical acclaim in a short career span (1992-2003).
Tarafdar, Manjima
core   +1 more source

The Temple as a Symbol of the Virgin Mary in Medieval Liturgical Hymns and Its Reflection in Images of the Annunciation of the 14th–15th Centuries

Religions
The current article seeks two interrelated objectives. First, we will shed light on the Mariological and Christological meanings underlying the saying templum Dei and other similar metaphorical expressions, with which countless medieval liturgical hymns,
José María Salvador-González
doaj   +1 more source

Real‐World Trends in Prenatal Antirheumatic Drug Utilization in Ontario, Canada: A Cross‐Sectional Time‐Series Analysis

Arthritis Care &Research, EarlyView.
Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah, Swaleh Hussain, Sara J. T. Guilcher, Lisa M. McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous   +6 more
wiley   +1 more source

Hortus Conclusus: A Mariological Symbol in Some Quattrocento Annunciations, According to Church Fathers and Medieval Theologians

Religions
This paper seeks to interpret the biblical metaphor of the hortus conclusus (closed garden) according to a Mariological projection, as presented iconographically in various Quattrocentro Annunciations. The author bases his interpretations on the exegesis
José María Salvador-González
doaj   +1 more source