Results 161 to 170 of about 6,354 (298)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Application of AI to Ultrasonographic Images to Aid the Clinical Care of Pregnant Women With Pre-eclampsia in Uganda: A Protocol for a Pilot Study. [PDF]

Cureus
Godfrey MR, Atwiine F, Atukunda EC, Celi LA, Mwavu R, Kaggwa F, Haberer JE, Wasswa W.   +7 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Patriarchal dominance, employment anxiety and subjective career success among career widows in Nigeria. [PDF]

BMC Psychol
Obi-Anike HO, Edore JO, Daniel OC, Imhanrenialena BO, Enemuo JI, Nnam DC, Onyemachi CA.   +6 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Arctic sea-ice ridges are biomass hotspots harboring diverse microbial communities. [PDF]

Commun Earth Environ
Müller O, Gardner J, Olsen LM, Salganik E, Assmy P, Gradinger R, Bratbak G, Hoppe CJM, Lange BA, Muilwijk M, Divine DV, Aberle N, Krause JW, Reigstad M, Leu E, Tsagaraki TM, Larsen A, Høyland KV, Balmonte JP, Boulton W, Dahle H, Eggers L, Fong AA, Guillou G, Lebreton B, Metfies K, Mock T, Petelenz E, Tatarek A, Torres-Valdés S, Torstensson A, Wiktor J, Granskog MA.   +32 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

The Divine Comedy of Dante Alighieri Volume 3: Paradiso

One of the greatest living Italian-to-English translators, Durling has at last completed his rendition of the third and final volume of Dante's masterful literary epic, The Divine Comedy.
Martinez, Ronald L., Durling, Robert M.
core  

Eco-cultural synergy: exploring the links between native trees, rituals, and conservation in Guji Society, Southern Ethiopia. [PDF]

J Ethnobiol Ethnomed
Roba GO.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source