Results 201 to 210 of about 234,582 (307)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The Grief experiences of Arab parents bereaved by blood feuds in Israel. [PDF]

Eur J Psychotraumatol
Abo-Mokh I, Sabar-Ben-Yehoshua N, Maree W, Frei-Landau R.   +3 more
europepmc   +1 more source

A Critical Introduction to the Book of Genesis

, 1960
Kim, Suk
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A qualitative exploration of deterrents to COVID-19 vaccination uptake among adults in post-war Tigray, Northern Ethiopia. [PDF]

Sci Rep
Tesfa FH, Kahsay ZH, Tesfean T, Ayaliew Werkneh A, Ayele B, Hadgu T, Gebretnsae H, Mekonnen M, Fisseha A, Gebreyohannes Y, Kenyi J, Mon HS, Kahsay H, Asmelash A, Gebrekurstos G, Alemayehu M, Medhanyie AA.   +16 more
europepmc   +1 more source

Electron: Greek Etymology and Baltic Mythology [PDF]

, 2013
Olcott, Marianina Demetri
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Food in Daniel 1:1-16: the first report of a controlled experiment? [PDF]

J R Soc Med
Weingarten S.
europepmc   +1 more source

Human Contingency, Divine Freedom, and the Normative Shape of Saving History [PDF]

, 2013
Rossi, Philip J.
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source