Results 231 to 240 of about 551,983 (304)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

DIVINE-pilot trial: a phase 2 multicentre, randomised pilot trial of pharmacotherapy and physical activity monitoring conducted in women with recent gestational diabetes and increased risk of type 2 diabetes recruited from tertiary referral hospitals in Australia. [PDF]

BMJ Open
Chen AX, Lee VY, Donges K, Giancas C, Angell B, Parmenter B, Barrett HL, Henry A, Patel A, Arnott C.   +9 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

What does resilience and well-being mean to community health workers? An exploratory study in the upper east region, Ghana. [PDF]

BMJ Public Health
Sakeah JK, Addiss D, Feng CX, Sakeah E, Asaana P, Gyapong M, Colman I, Krentel A.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Multianalytical Study of Amuletic and Talismanic Islamic-African Paper Manuscripts in the Slovene Ethnographic Museum. [PDF]

Chempluschem
Elnaggar A, Mahgoub H, Maestro-Guijarro L, Crespo Ibáñez A, María Carmona-Quiroga P, Sánchez-Cortés S, Rehar Ž, Kos G, Ameen A, Frelih M, Strlič M, Oujja M, Castillejo M.   +12 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Applying the socioecological model to examine the beliefs, perceptions and attitudes surrounding preterm birth in Ethiopia: a qualitative study. [PDF]

BMJ Open
Estifanos AS, Gelaw MA, Getachew H, Ireso BR, Dimtse A, Metaferia G, Woldehawariat TD, Walelegn M, Magge H, Roro MA, Gobena RG, Nigatu YD, Mengistu Y, Shikur B, Demissew R, Beyene SA, Tumilowicz A.   +16 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Defining End-of-Life Preparedness: A Dyadic Qualitative Study of Hispanic Patients with Advanced Breast Cancer and Their Caregivers. [PDF]

Healthcare (Basel)
Rosario-Ramos LP, Quiles-Bengochea C, Laporte-Estela G, Rivera N, Graulau-Burgos AM, Peña-Vargas C, Hernández-Torres R, Cortes-Castro C, Rodriguez-Castro Z, Castro-Figueroa EM, Torres-Blasco N.   +10 more
europepmc   +1 more source