Results 171 to 180 of about 2,517,735 (227)
Sequential Flow-Based Assessment of a Suspected Inferior Pancreaticoduodenal Artery-Derived Pathway Entering the Right Hepatic Artery during Pancreaticoduodenectomy: A Case Report. [PDF]
Saito Y +4 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
<i>Arabidopsis</i> TPXL Proteins Mediate a Selective Aurora Kinase-Microtubule Association During Cell Division. [PDF]
Cao S, Chen Y, Weng Z, Ren H, Du P.
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Special Issue "Cell Division: A Focus on Molecular Mechanisms". [PDF]
Colanzi A, Sechi S.
europepmc +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Defining the order of assembly of the <i>Clostridioides difficile</i> divisome complex. [PDF]
Harrison GA +5 more
europepmc +1 more source

