Results 181 to 190 of about 125,463 (212)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Correlates of Sexually Transmitted Infection (STI) Positivity and Implementation of Point-of-Care STI Testing at a Mobile Clinic for Women Who Inject Drugs in Seattle, WA. [PDF]

Sex Transm Dis
Fessler AG, Corcorran MA, Violette LR, Tapia KA, Fitzpatrick TS, Jones S, Austin EJ, Glick SN, Williams EC, Dhanireddy S, Stewart J.   +10 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Use of the Child Opportunity Index in Adolescent and Young Adult Health Research. [PDF]

J Adolesc Health
Luke MJ, Wood SM, Beck AF.
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Including "sexual" in sexual and reproductive health labor: Gendered experiences of sexually transmitted infection (STI) prevention, testing, and treatment among young people in Texas. [PDF]

Soc Sci Med
Whitfield B.
europepmc   +1 more source

HIV and Syphilis Testing Among Patients Tested for Gonorrhea and Chlamydia in Emergency Departments. [PDF]

West J Emerg Med
Sherwood K, Zhang N, David H, Dekker A, Garner O, Samuels E, Adamson P.   +6 more
europepmc   +1 more source

Seeing beyond the aesthetic problem of labia minora hypertrophy: a case report. [PDF]

Int J Surg Case Rep
Moegni F, Hidayah GN, Ksyatria YNI, Kouwagam AD, Mardhiyah T.   +4 more
europepmc   +1 more source

"We do anything to get alcohol": A mixed methods approach to explore the intersections between alcohol use and HIV risk and infection amongst adolescent girls and young women from high HIV-burdened communities in South Africa. [PDF]

PLoS One
Bergh K, Duby Z, De Man J, Ebrahim N, Kuo C, Lombard C, Williams PP, Jonas K.   +7 more
europepmc   +1 more source

Sexual Health and Relationship Education Needs of People in Recovery for an Opioid Use Disorder. [PDF]

Prev Sci
Wilkerson JM, Gallardo KR, Zoschke IN, Stewart HLN, Rodriguez SA, Anosike MU, Pullin J, McCurdy SA.   +7 more
europepmc   +1 more source