Results 161 to 170 of about 2,786,053 (297)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Education Research: Shaping the Future of Epilepsy Fellowship Training in Canada: A Canadian League Against Epilepsy Delphi Study. [PDF]

Neurol Educ
Datta AN, Ikeda KM, Salazar Cerda CI, Hadjinicolaou A, D'Onofrio G, Jacobs-LeVan J, Appendino JP, Kobayashi E, Ramachandrannair R, Bui E.   +9 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery. [PDF]

Proc Natl Acad Sci U S A
Drobnič T, Salzer R, Nierhaus T, Jiang MKX, Bellini D, Steindorf A, Albers SV, Baum B, Löwe J.   +8 more
europepmc   +1 more source

Effects of rpl1001 Gene Deletion on Cell Division of Fission Yeast and Its Molecular Mechanism [PDF]

Wen Yu, Rongmei Yuan, Mengnan Liu, Ke Liu, Xiang Ding, Yiling Hou   +5 more
openalex   +1 more source

Mitochondrial genomes of Anopheles arabiensis, An. gambiae and An. coluzzii show no clear species division [PDF]

, 2019
Mark Hanemaaijer, Parker D. Houston, Travis C. Collier, L.C. Norris, Abdrahamane Fofana, Gregory C. Lanzaro, Anthony J. Cornel, Yoosook Lee   +7 more
openalex   +1 more source

Division Notes [PDF]

Science, 1977
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Anaplastic large-cell lymphoma mimicking cellulitis in an 8-year-old boy. [PDF]

CMAJ
Bourque M, Coulombe J.
europepmc   +1 more source

CHEMISTRY DIVISION QUARTERLY REPORT, DECEMBER 1952, JANUARY, FEBRUARY 1953; THE SOLUBILITY OF HYDROGEN AND DEUTERIUM IN VARIOUS SOLVENTS

, 1953
M. W. Cook, Donald N. Hanson
openalex   +1 more source