Results 211 to 220 of about 6,584,437 (368)

Inefficiencies in the division of labour in human societies. [PDF]

open access: yesPhilos Trans R Soc Lond B Biol Sci
Diehl C, Preisendörfer P.
europepmc   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

open access: yesFEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia   +5 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Corrigendum to "A phase II study of tepotinib in patients with advanced solid cancers harboring MET exon 14 skipping mutations or amplification (KCSG AL19-17)": [ESMO Open 9 (2024) 103668]. [PDF]

open access: yesESMO Open
Kang EJ   +17 more
europepmc   +1 more source

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