Results 71 to 80 of about 2,786,053 (297)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Petras Vileišis (1851–1926) as the Pioneer in creating Lithuanian “Arithmetic”

open access: yesLietuvos Matematikos Rinkinys, 2009
Petras Vileišis (1851–1926) is one of the most prominent Lithuanian personalities at the end of the 19th c. and the beginning of the 20th c., who was distinguished for his universal activity.
Juozas Banionis
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

A Logic Object and its State

open access: yesActa Polytechnica, 2001
This paper shows not only that the state of an objecty parameterizes the dyad (stimulus, response) but that it is also the performer of the state transition initiated by the stimulus.
J. Bokr, V. Jáneš
doaj  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Urban waterfronts as a deserted heritage. Gubin-Guben case study / Apleistas miesto krantinių paveldas. Gubino ir Gubeno pavyzdys

open access: yesMokslas: Lietuvos Ateitis, 2015
The article discusses the process of changing the shape of urban waterfronts by the Lusatian Neisse River in Gubin and Guben, comparing the post-war urban solutions with the pre-war ones.
Oskar Amiri
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Multimodal Languaging as a Pedagogical Model—A Case Study of the Concept of Division in School Mathematics

open access: yesEducation Sciences, 2017
The purpose of this study is to present a multimodal languaging model for mathematics education. The model consists of mathematical symbolic language, a pictorial language, and a natural language.
Jorma Joutsenlahti, Pirjo Kulju
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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