Results 41 to 50 of about 290,510 (307)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Algorithm approach of division in Mathematics didadic books for the initial years
Educação Matemática Debate, 2018 We investigate how the algorithms of the division of natural numbers are approached in didactic books of Mathematics of the initial years of elementary school, we mapped activities in which they are approached; and we analyze the use of division ...
André Pereira da Costa +3 more
doaj +1 more source
A module classification method for light industrial equipment based on improved NSGA2-FCM algorithm
Scientific Reports, 2023 In response to the problem that it is easy to fall into local optimum when using the traditional clustering algorithm to divide the modules, this paper improves the initialisation strategy of the NSGA2 algorithm and combines it with the FCM algorithm to ...
Hui Zheng +4 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Cell Scene Division and Visualization Based on Autoencoder and K-Means Algorithm
IEEE Access, 2019 For the network service construction and optimization of wireless cell, the effective scene division is an important basis for formulating more accurate network construction schemes and optimization strategies.
Jun Zeng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
An Algorithm for Exact Division
Journal of Symbolic Computation, 1993 Division of long integers is a frequently performed task in computer algebra. The common algorithms used for that purpose rely on computing quotient and remainder (IQR), even when it is known in advance that the latter one is zero. The author proposes to exploit the fact that the division is exact and gives a time-saving algorithm (EDIV) starting from ...
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Chairux Algorithm for Divisibility Test
Asian Journal of Advanced Research and Reports, 2023 This paper presents a novel Chairux Algorithm for the divisibility test. The test is based on an arbitrary integer via the concepts of Bezout’s identity and the Euclidean algorithm. Examples demonstrating the effectiveness of the proposed algorithm indicate its simplicity, efficiency, and flexibility compared to the existing state-of-the-art algorithms.
Charles Irungu Mwangi, Moses Otieno Ouma
openaire +1 more source