Results 71 to 80 of about 290,510 (307)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

Regional division and reduction algorithm for minimizing the sum of linear fractional functions

open access: yesJournal of Inequalities and Applications, 2018
This paper presents a practicable regional division and cut algorithm for minimizing the sum of linear fractional functions over a polyhedron. In the algorithm, by using an equivalent problem (P) of the original problem, the proposed division operation ...
Pei-Ping Shen, Ting Lu
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A novel localization approach for underwater welding vehicles in spent fuel pools via attitude heading reference system and altimeters

open access: yesInternational Journal of Advanced Robotic Systems, 2019
In this article, a novel localization approach incorporating attitude and heading reference system and underwater altimeters is presented to accurately localize the underwater welding vehicles in spent fuel pools of the nuclear power stations.
Yang Luo   +8 more
doaj   +1 more source

Analysis of the psicometric properties of a multiplication and division processes assessment scale

open access: yesINFAD, 2019
The domain of multiplication and division operations depends on both algorithm management and the ability to identify the semantic structure of the problem and to translate it into mathematical language.
Yazna Cisternas Rojas   +3 more
doaj   +1 more source

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