Results 71 to 80 of about 235,807 (262)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

p-adic properties of division polynomials and elliptic divisibility sequences [PDF]

Mathematische Annalen, 2004
For a given point P in the group of K-rational points E(K) of an elliptic curve, we consider the sequence of values (F_1(P),F_2(P),F_3(P),...) of the division polynomials of E at P. If K is a finite field, we prove that the sequence is periodic. If K/Q_p is a local field, we prove (under certain hypotheses) that there is a power q=p^e so that for all m
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tax distortions in cross-border flows of intangible assets

International Journal of Innovation Studies, 2018
The phenomenon of global fragmented production and associated trade in intermediate products, including intangible assets, has changed how economists study globalization and how new public policies are shaped.
Thomas Neubig, Sacha Wunsch-Vincent
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

FEATURESOFDEVIDING SPOUSES’ COMMUNITYDEBT

Вестник Кемеровского государственного университета, 2013
In the paperaddresses one of the pressing issues of private law relations – features of dividing debt within marital property. The author focuses on the general dispositive aspects in the regulation of spouses’property relations, which gives them the ...
N. S. Shcheglova
doaj  

Natural Language Processing Risk Assessment Application Developed for Marble Quarries

Applied Sciences
In this study, by using the texts describing the hazards and precautions taken during text mining, the necessary processes were carried out to first estimate the probability value and severity value of the risk and then calculate the risk values by ...
Hasan Eker
doaj   +1 more source

ORZEKANIE O PODZIALE MAJĄTKU WSPÓLNEGO MAŁŻONKÓW W ŚWIETLE BADAŃ AKTOWYCH

Zeszyty Prawnicze, 2016
RULINGS ON THE DIVISION OF MATRIMONIAL ASSETS IN THE LIGHT OF RESEARCH ON COURT RECORDS Summary The article discusses the division of matrimonial assets in Poland after the cessation of community property.
Jerzy Słyk, Dominika Godlewska
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source