Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
THE STUDY OF THE EVOLUTION OF THE RESIDENT POPULATION IN ROMANIA ACCORDING TO NATURAL MOVEMENT [PDF]
Starting from the fact that 2022 is the year in which Romania carried out the most recent population census in Romania, this article aims to analyze the evolution over time of the resident population in Romania, according to the main indicators that ...
NADIA ELENA STOICUȚA
doaj
In the Shadow of a Myth: Bargaining for Same-Sex Divorce [PDF]
This Article explores a relatively new phenomenon in family law: same-sex divorce. The Article\u27s central claim is that parties to the first wave of same-sex divorces are not effectively bargaining against the backdrop of legal dissolution rules that ...
Ben-Asher, Noa
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Effect of Divorce on Women's Employment: An Application for Turkey with Regional Data
The issue of employability is an important macroeconomic matter for today's economies. Especially, some policies aimed at increasing women's employment are being applied by many countries and various policy instruments are trying to eliminate the factors
Demet Eroğlu Sevinç
doaj +1 more source
The divorced and who divorces? [PDF]
The Family Resources Survey was used to identify the characteristics of the divorced population and two longitudinal studies, the British Household Panel Survey (BHPS) and the National Child Development Study (NCDS) were used to address the question 'who
Kiernan, Kathleen, Mueller, Ganka
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The Impact of Divorce Cooling-Off Period on Registered Divorces: Evidence from China
The divorce rate in China has continued to rise since the 21st century. In order to reduce impulsive divorces, the divorce cooling-off period (DCOP) system was established in the Civil Code of China.
Wenge Zheng, Bowen Niu, Zhenguo Chen
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source

