Results 81 to 90 of about 61,518 (280)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Statistical assessment of interrelationship of marriage and divorces to fertility
Вестник университетаThe methodology for analyzing interrelationship of marriage and divorces to fertility has been proposed, approbation of which has been carried out on the basis of the modern system of statistical accounting, which allowed to form a unique system of ...
A. B. Sinelnikov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Frequency of marriages and divorces in Republic Bashkortostan in 1984-2007
RUDN Journal of Medicine, 2009 There are has been studied frequency of marriages and divorces and their influence on birth rate in Republic Bashkortostan in 1984-2007 гг. Decrease of marriages and increase of divorces was accompanied by reduction of birth rate in the investigated ...
Z M Soultanaeva, N Kh Sharafutdinova
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Ending Process of the Family Union in Ayntab City (1600–1650)
Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2011 Family is a social institution consisting of mother, father and children living under the same roof. In this study; the ending process of family institution which is one of the most important establishment in the foundation of a society in Ayntab city in
Zülfiye KOÇAK
doaj
An empirical analysis of the effect of labour market characteristics on marital dissolution rates [PDF]
The development in the 1960s of the divorce rate is strikingly similar for the USA and Denmark where the rate in both cases increases very fast from 1967-68 until the mid 1970s.
Bentzen, Jan, Smith, Valdemar
core
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source