Results 101 to 110 of about 17,391 (234)

PMDA Perspective on Use of Real‐World Data and Real‐World Evidence as an External Control: Recent Examples and Considerations

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 910-919, April 2025.
Recent discussions about the utilization of real‐world data (RWD) and real‐world evidence (RWE) have been more focused on drug development for regulatory approval rather than during the post‐marketing stage. In Japan, RWD/RWE have been practically utilized as an external control for drug approval.
Junichi Asano   +5 more
wiley   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi   +9 more
wiley   +1 more source

Clinicopathological Features of Mixed Connective Tissue Disease‐Related Myositis: A Case Series

open access: yesMuscle &Nerve, Volume 71, Issue 4, Page 583-592, April 2025.
ABSTRACT Introduction Mixed connective tissue disease (MCTD) patients often have myositis, however, myopathological and clinical data for MCTD are limited. Recent reports have shown that the pathology of MCTD myositis resembles that of immune‐mediated necrotizing myopathy (IMNM), whereas earlier reports described perifascicular atrophy or inflammatory ...
Naohiro Sakamoto   +4 more
wiley   +1 more source

Preoperative DLco and FEV1 are correlated with postoperative pulmonary complications in patients after esophagectomy

open access: yesScientific Reports
Limited information is available regarding the association between preoperative lung function and postoperative pulmonary complications (PPCs) in patients with esophageal cancer who undergo esophagectomy. This is a retrospective cohort study.
Taeyun Kim   +17 more
doaj   +1 more source

Pediatric Pulmonology 2024 Year in Review: Rare and Diffuse Lung Disease

open access: yesPediatric Pulmonology, Volume 60, Issue 4, April 2025.
ABSTRACT The field of pediatric rare and diffuse lung diseases continues to advance, with ongoing research deepening our understanding of the diagnosis and treatment of conditions such as children's interstitial and diffuse lung disease (chILD), non‐cystic fibrosis (CF) bronchiectasis, and pulmonary complications of childhood cancer.
Pi Chun Cheng   +3 more
wiley   +1 more source

Heart Rate Variability as a Marker of Disease Severity in Pulmonary Arterial Hypertension: A Prospective Cohort Study

open access: yesPulmonary Circulation, Volume 15, Issue 2, April 2025.
ABSTRACT Pulmonary arterial hypertension (PAH) is a disease that can eventually progress to right ventricular failure. Heart rate variability (HRV), including standard deviation of R‐to‐R intervals (SDNN), has been associated with increased mortality across different populations.
Arun Jose   +4 more
wiley   +1 more source

A Prospective Analysis of Vasoreactivity and Mortality in WHO Group 3 Pulmonary Hypertension

open access: yesPulmonary Circulation, Volume 15, Issue 2, April 2025.
ABSTRACT Prognostic markers of Group 3 pulmonary hypertension (PH) remain largely unknown. In this study, we evaluate clinical data to provide a comprehensive profile of patients with Group 3 PH and evaluate the potential use of vasoreactivity testing as a prognostic tool within this population.
Daniel J. Strick   +6 more
wiley   +1 more source

Prognostic implication of 1-year decline in diffusing capacity in newly diagnosed idiopathic pulmonary fibrosis

open access: yesScientific Reports
The progression of idiopathic pulmonary fibrosis (IPF) is assessed through serial monitoring of forced vital capacity (FVC). Currently, data regarding the clinical significance of longitudinal changes in diffusing capacity for carbon monoxide (DLCO) is ...
Hyeonsu Lee   +5 more
doaj   +1 more source

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