Results 1 to 10 of about 39,022 (246)

Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long-Acting Injectables - Where to Begin With Critical Bioavailability Attributes? [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Long‐acting injectables (LAI) are of increasing interest as they facilitate improved medication adherence and exposure, with target plasma concentration levels maintained over weeks/months. Biopredictive in vitro dissolution tests can aid formulation development of LAIs and guide quality control dissolution testing by facilitating accelerated ...
Cleary H, Fotaki N, Persoons T, D'Arcy DM.   +3 more
europepmc   +2 more sources

Bayesian Ordered Lattice Design for Phase I Clinical Trials. [PDF]

Stat Med
ABSTRACT We develop a new framework specifically for early Phase I clinical trials called Bayesian Ordered Lattice Design (BOLD). This study is motivated by two key factors. First, Phase I clinical trials typically involve relatively small sample sizes, which can make the use of prior information on dose‐limiting toxicity (DLT) rates highly significant.
Wang GM, Tatsuoka C.
europepmc   +2 more sources

Double-Lumen Intubation Facilitating a Single-Anesthesia Workflow in Robot-Assisted Navigational Bronchoscopy and Subsequent Lung Resection: A Single-Center, Retrospective Study. [PDF]

J Clin Med
Menghesha H, Arensmeyer J, Feodorovici P, Coburn M, Skowasch D, Kütting D, Schmidt J, Zalepugas D.   +7 more
europepmc   +1 more source

Etiology and management of iatrogenic tracheobronchial injuries by double-lumen tubes in thoracic surgeries: a case series of 7 patients. [PDF]

BMC Anesthesiol
Liu H, Chen J, Ran Q, Liu Z, Bo Y, Gao Q, Chen M, Liu J.   +7 more
europepmc   +1 more source

Pre-shaping double-lumen endotracheal tubes based on video laryngoscope blade curvature enhances first-attempt intubation success rate in patients undergoing thoracoscopic surgery: a randomized controlled trial. [PDF]

Front Med (Lausanne)
Yang Y, Liu Q, Xiao F, Yang L, Liu H, Wang Y, Liu M, Tang J, Wang Q, Lv J, Zhang H, Xu L, Wang W.   +12 more
europepmc   +1 more source

Patient Retreat in Dose Escalation for Phase I Clinical Trials With Rare Diseases. [PDF]

Stat Med
Fang J, Yin G.
europepmc   +1 more source

Comprehensive Tracheobronchial Morphometry in Korean Adults: Clinical Implications for Double-Lumen Tube Sizing and Right Upper Lobe Alignment. [PDF]

J Clin Med
Min S, Cho YJ, Bahk JH.
europepmc   +1 more source

Novel Triple-Cuff versus Conventional Double-Cuff Double-Lumen Endobronchial Tube in Patients with Risk Factors for Tube Misdirection. [PDF]

Yonsei Med J
Kim N, Oh YJ, Kim HJ, Lee K.
europepmc   +1 more source

Trabectedin plus CD13-targeted tissue factor tTF-NGR against advanced relapsed or refractory soft tissue sarcoma: translational data, clinical safety and efficacy. [PDF]

Sci Rep
Hessling K, Brand C, Schwöppe C, Gerwing M, Pavelka S, Berdel AF, Hintelmann H, Hamacher R, Müller-Tidow C, Egerer G, Hartmann W, Grünewald I, Lindner LH, Di Gioia D, Hecker JS, Maurer S, Pink D, Fried M, Zapata Bonilla SA, Scheuble AM, Lordick F, Ivanyi P, Fobker M, Lenz G, Gerss J, Kessler T, Berdel WE, Schliemann C.   +27 more
europepmc   +1 more source

Entropy guided multi level feature fusion network for high precision content based image retrieval. [PDF]

Sci Rep
Lavanya M, Vennira Selvi G, Gopi R, Vimal Raj AC.   +3 more
europepmc   +1 more source