Results 211 to 220 of about 51,552 (283)

DMD in Cyprus: Demographics and clinical characteristics

Background: In Cyprus over the past years various interventions have been implemented, such as genetic counselling, national neonatal screening program for CPK, steroid treatment and ventilation support, in order to reduce the incidence of the disease ...
Lochmuller H, Yiangou A, Lavranos G, Nikolenko N   +3 more
core  

PLP Homeostasis Protein Is Required for Efficient Maturation of Aromatic Amino Acid Aminotransferase in Salmonella enterica

Molecular Microbiology, EarlyView.
Cellular pool of aromatic amino acid aminotransferase proteins represented as holo‐ or apo‐ enzymes, reflecting presence or absence of associated PLP. Status of PLPHP is implicated in determining the ratio of holo‐ and apo‐TyrB. ABSTRACT Pyridoxal 5′‐phosphate (PLP) is an essential cofactor required for metabolic functions including amino acid ...
Brandi A. Buckner, Diana M. Downs
wiley   +1 more source

YAP Acts as a Negative Regulator of Mini Utrophin-Based Gene Therapy for Duchenne Muscular Dystrophy in Mdx Mice. [PDF]

Int J Mol Sci
Li Z, Song Y.
europepmc   +1 more source

Thioredoxin system modulates metabolic and stomatal responses to elevated CO2 in Arabidopsis

New Phytologist, EarlyView.
Integrative model of extraplastidial NADPH‐dependent thioredoxin reductase/thioredoxin system‐mediated regulation of stomatal function, redox homeostasis, and metabolic responses under ambient and elevated CO2 in Arabidopsis thaliana. Summary The NADPH‐dependent thioredoxin reductase/thioredoxin (NTR/TRX) system plays a central role in maintaining ...
Paula da Fonseca‐Pereira, Domingos F. Mélo Neto, Rita de Cássia Monteiro‐Batista, Daniel Gomes Coelho, Jaciara Lana‐Costa, Leonardo Perez de Souza, Ina Krahnert, Danilo M. Daloso, Jorge Gago, Alisdair R. Fernie, Wagner L. Araújo, Adriano Nunes‐Nesi   +11 more
wiley   +1 more source

Cognitive deficits linked to intrinsic timescales and gray matter volume abnormalities in children with Duchenne muscular dystrophy. [PDF]

J Neurodev Disord
Niu X, Hu Q, Zhang X, Zhang S, Xu K, Xu R, Song Y, Fu H, Zhou Z, Ren Y, Li C, Xu T, Han S, Zhang Y, Xu H, Cai X, Cheng B, Guo Y.   +17 more
europepmc   +1 more source

Effects of photobiomodulation therapy on pulmonary inflammation in chronic asthma: Dosimetric study in an experimental model

Photochemistry and Photobiology, EarlyView.
Photobiomodulation therapy (PBMT) was evaluated across a radiant energy range (1–7.5 J) in a murine model of chronic ovalbumin‐induced asthma to identify the optimal therapeutic dose. PBMT attenuated airway inflammation and remodelling, suppressed Th2 cytokines, and enhanced regulatory immune responses, highlighting a dose‐dependent immunomodulatory ...
Tawany Gonçalves Santos, Cintia Estefano Alves, Bibiana Padilha de Menezes da Silva, Cinthya Cosme Gutierrez Duran, Stella Zamuner, Rodrigo Labat, José Antonio Silva Junior, Maria Cristina Chavantes, Flavio Aimbire, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira   +10 more
wiley   +1 more source

Long-read sequencing identifies complex structural variants in DMD patients. [PDF]

BMC Med Genomics
Xie Y, Bao L, Yu X, Liu Y.
europepmc   +1 more source

An Account of Luck, Fortune, and Fate

Philosophy and Phenomenological Research, EarlyView.
ABSTRACT Luck is one of our most important concepts. In this article, I first argue that extant accounts of luck are deeply flawed. I then argue for a hybrid account of luck that is based around the difference between skill‐based and non‐skill‐based events.
Jesse Hill
wiley   +1 more source

Estimating health-state utility values for family-caregivers of patients with Duchenne muscular dystrophy using time trade-off valuation. [PDF]

J Patient Rep Outcomes
Borecka O, Llewellyn S, Woollacott I, Richardson L, Fellows A, Lawrence J, Bottomley C, Biggane AM.   +7 more
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source