Results 61 to 70 of about 38,473 (244)

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Analysis of Flow-induced Vibration Characteristics of Fuel Rods Using POD and DMD Methods

Yuanzineng kexue jishu
The exploration of flow-induced vibration in fuel rods is of utmost importance as it plays a pivotal role in comprehending and mitigating factors that contribute to fuel failure and reactor shutdown.
MIN Guangyun1, JIANG Naibin1, 2,
doaj   +1 more source

Generation and characterization of an induced pluripotent stem cell line (ZSYYDNi001-A) from a patient with Duchenne muscular dystrophy carrying exon 51 deletion in the DMD gene

, 2021
Liang Wang, Huan Li, Yaqin Li, Min Xu, Jinfu Lin, Ziyu Liao, Zhong Pei, Cheng Zhang   +7 more
openalex   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Central giant cell granuloma of the mandibular condyle: a case report, literature review, and discussion of treatment

Oral and Maxillofacial Surgery Cases, 2015
Benign and malignant neoplasms of the temporomandibular joint are uncommon. Their presence poses a diagnostic and therapeutic challenge for clinicians.
Jordan Gigliotti, DMD, Osama Alghamdi, DMD, Michel El-Hakim, DMD, MD, MSc, Nicholas Makhoul, DMD, MD   +3 more
doaj   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Przymuszała M, Białobrzeska M, Dulak J, Florczyk-Soluch U.   +3 more
europepmc   +2 more sources

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Live‐imaging of revertant and therapeutically restored dystrophin in the Dmd^EGFP‐mdx mouse model for Duchenne muscular dystrophy [PDF]

, 2020
Mina Petkova, Amalia Stantzou, A. Morin, Olga N. Petrova, Susanne Morales-Gonzalez, Franziska Seifert, J. Bellec-Dyèvre, Tudor Manoliu, Aurélie Goyenvalle, Laurynn Garcia, Isabelle Richard, Corinne Laplace‐Builhé, Markus Schuelke, Helge Amthor   +13 more
openalex   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Implementation of the quality-by-design concept for an adeno-associated viral vector-based gene therapy

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Currently, manufacturers of adeno-associated virus (AAV)-based gene therapy products are facing a number of systemic problems stemming from the difficulties in assessing the quality of medicinal products due to insufficient scientific data,
D. S. Kopein, G. N. Poroshin, R. A. Khamitov   +2 more
doaj   +1 more source