Results 151 to 160 of about 11,938 (307)

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

A nomogram based on nutritional and inflammatory parameters to predict DMFS and identify beneficiaries of adjuvant chemotherapy in IVA-stage nasopharyngeal carcinoma

Objective This study aims to develop a nomogram integrating inflammation (NLR), Prognostic Nutritional Index (PNI), and EBV DNA (tumor burden) to achieve personalized treatment and prediction for stage IVA NPC.
Ying Li, Jinghua Lai, Wenquan Hong, Yuhui pan, Sunqin Cai, Sufang Qiu, Zihan Chen, Zongwei Huang, Jun Lu   +8 more
core   +1 more source

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy

Advanced Science, EarlyView.
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
wiley   +1 more source

Rapid In Vitro Pathological Diagnosis of Glioma Using Dual‐Color Quantum Dot Probes for Precise Intraoperative Resection

Advanced Science, EarlyView.
Glioma resection surgery is challenging because of the infiltrative growth of the tumor into nearby tissue and the different surgical requirements for gliomas with different mutation types. To improve the precision and effectiveness of glioma resection, this study developed a new imaging probe that enables the tumor boundary and mutation status to be ...
Dongdong Wu, Chenxuan Yang, Yuanbin Wu, Minghang Liu, Yizhi Zhang, Yuang Cai, Yibo Zhang, Jimei Chi, Hengchao Ma, Ding Zhang, Chenqing Liu, Meng Su, Guochen Sun   +12 more
wiley   +1 more source

Durable benefits, but no improvements in overall survival: what can we learn from CheckMate 238 after 9 years of follow-up? [PDF]

Transl Cancer Res
Lopes CDH, Spreafico A, Araujo DV.
europepmc   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source

The clinical value of clinical treatment score post-5 years in patients with premenopausal breast cancer: a retrospective analysis of ASTRRA trial. [PDF]

Breast
Han Y, Kim HJ, Baek SY, Ahn SH, Ryu JM, Kim SI, Lee EG, Im SA, Jung Y, Park MH, Park KH, Kang SH, Jeong J, Park E, Kim SY, Lee MH, Kim LS, Lim W, Noh WC, Kim S, Kim HA.   +20 more
europepmc   +1 more source

Mechanochemical Piezoelectric Catalysis: Advancing the Hydrogenation of Alkenes

Advanced Science, EarlyView.
This study presents mechanochemical piezoelectric catalysis for alkene hydrogenation, eliminating the need for transition metals, H2, and solvents. The method effectively hydrogenates diverse activated and unactivated alkenes and shows potential for modifying bioactive molecules in pharmaceuticals.
Zixi Ai, Mengting Liu, Xiaohong Wang, Xiaochun He, Xuemei Zhang, Zhong Lian   +5 more
wiley   +1 more source

Yedi-on iki yaş grubu çocuklarda ağızda Candida sıklığı, dfs ve DMFs skorları ile candida arasındaki ilişki

, 1999
Candida' lar normal ağız florasında bulunan ve genellikle fırsatçı patojen olarak tanınan mikroorganizmalardır. Bugüne kadar diş çürüğü ile Candida'lar arasında kanıtlanmış bir ilişki bulunmamasına karşın son yıllarda Candida türlerinin de çürük ...
Süleyha Hilmioğlu, Ali Rıza Alpöz, Işıkgöz Meltem Taşbakan   +2 more
core  

Treatment and clinical outcomes among stage II-IVA nasopharyngeal carcinoma patients with undetectable pretreatment Epstein-Barr viral DNA. [PDF]

Front Med (Lausanne)
Sun CM, Xu Z, Li CH, Chen JX, Su XY, Song JX, Song SH, Xu QQ, Wu YL.   +8 more
europepmc   +1 more source