A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu +8 more
wiley +1 more source
Lower-neck involvement and post-concurrent chemoradiotherapy response predict distant metastasis in head and neck cancer. [PDF]
Kim D +8 more
europepmc +1 more source
Guided by a Random Forest model, a π–π‐driven ordered stacking strategy deploys functionally distinct substructures to restrict chain segment motion and increase free volume, while preserving the intermolecular interactions that maintain structural integrity.
Zi‐Meng Xu +10 more
wiley +1 more source
Comparative outcomes of conventional versus endoscopic-assisted surgery for breast phyllodes tumors: a single center retrospective cohort study. [PDF]
Zhuang Z +10 more
europepmc +1 more source
Butterfly wing–inspired intrinsically self‐healing polymer interlayers enable flexible perovskite optoelectronics with high luminance, strain‐insensitive stability, and environmental resilience. These hierarchically structured films redistribute mechanical stress, suppress defect formation, and maintain performance under repeated bending, paving the ...
Loganathan Veeramuthu +13 more
wiley +1 more source
Diffusion weighted imaging-based tumor growth rate for predicting long-term survival in nasopharyngeal carcinoma. [PDF]
Yang F +12 more
europepmc +1 more source
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Feasibility of omitting regional nodal irradiation in cT1-2N1 breast cancer with ypN1 disease after neoadjuvant chemotherapy (KROG 21-06). [PDF]
Park Y +15 more
europepmc +1 more source
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu +6 more
wiley +1 more source
Indirect Comparison of the Efficacy of Pembrolizumab Versus Nivolumab as Adjuvant Options for Stage IIB/IIC Melanoma. [PDF]
Andreikos DA +8 more
europepmc +1 more source

