Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Long-Term Survival Outcomes of Concurrent Chemoradiotherapy for Postoperative High-Risk Salivary Gland Carcinomas. [PDF]
Dou S +7 more
europepmc +1 more source
[On the value of DMF index and DMF numbers in the light of personal experiences].
openaire +1 more source
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan +6 more
wiley +1 more source
New Perspectives and Open Issues in the Adjuvant and Neoadjuvant Treatment of Melanoma. [PDF]
Spagnoletti A +14 more
europepmc +1 more source
Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF6
A photocatalytic single electron reduction strategy is reported for the activation and valorization of sulfur hexafluoride (SF6), a potent greenhouse gas. Under mild conditions, SF6 is reduced to generate pentafluorosulfanyl (SF5) radicals, enabling direct access to pentafluorosulfanyl ketones, acetals, and BCP motifs.
Chen‐Hui Jiang +11 more
wiley +1 more source
A multimodal biological margin risk index predicts recurrence after neoadjuvant immunochemotherapy in head and neck squamous cell carcinoma. [PDF]
Xu N +6 more
europepmc +1 more source
Enhanced Stability in Zero‐Excess Li‐Metal Batteries via Prelithiated Carbon Nanofiber Interlayers
Carbon nanofibers carbonized at 700°C show Li metal deposition predominantly on the side facing the Cu current collector. During delithiation, Li agglomerates remain as inactive lithium on the fiber surface. This behavior can be changed by a modified n‐Buli prelithiation without a washing step, suppressing dead Li formation and therefore enabling ...
Sandro Schöner +11 more
wiley +1 more source
β‐side chain elimination enables cost‐effective fused‐ring acceptors, JSM5 and JSM6, with simplified synthesis. The observed compact tetrameric structures induced by S···N intermolecular interactions lead to 3D charge transport and enhance intermolecular connectivity, delivering high short‐circuit current density up to 28 mA cm−2, a step closer to the ...
Jinhui Zhao +14 more
wiley +1 more source
Investigating oral microbiome profiles of children with cleft lip and palate in different states of caries. [PDF]
Shi Z +5 more
europepmc +1 more source

