Results 211 to 220 of about 256,976 (337)

The gut microbiota remodes amino acid and lipid metabolism in incomplete revascularization of CHD with phlegm-dampness syndrome: an integrated multiomics and network pharmacology study. [PDF]

Front Mol Biosci
Zhang X, Jiang W, Li X, Xu W, Liu T, Cao H, Zhao H, Shi W, Lan T, Lu W.   +9 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Diverse database and machine learning model to narrow the generalization gap in RNA structure prediction. [PDF]

Sci Adv
de Lajarte AA, Taillades YJMD, Aruda J, Bongrand P, Wightman FF, Salazar D, Allan MF, Kalicki C, L'Esperance-Kerckhoff C, Kashi A, Jossinet F, Rouskin S.   +11 more
europepmc   +1 more source

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes.

Blood, 2014
A. Eckly, H. Heijnen, F. Pertuy, Willie J. C. Geerts, F. Proamer, Jean-Yves Rinckel, C. Léon, F. Lanza, C. Gachet   +8 more
semanticscholar   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

In vitro cytotoxic mechanisms of Pt(O,O'-acac)(γ-acac)(DMS): mitochondrial dysfunction and impaired autophagy in U251 cell line. [PDF]

Cell Death Discov
Gaiaschi L, De Luca F, Girelli CR, Milanesi G, Roda E, Fanizzi FP, Grimaldi M, Bottone MG.   +7 more
europepmc   +1 more source

A meta‐analysis of oceanic DMS and DMSP cycling processes: Disentangling the summer paradox

, 2015
M. Galí, R. Simó
semanticscholar   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

The Serotonin 1B Receptor Modulates Striatal Activity Differentially Based on Behavioral Context. [PDF]

eNeuro
Ng KH, Sharma A, Nautiyal KM.
europepmc   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source