Results 241 to 250 of about 254,372 (361)

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Large-scale functional assessment of variants of the potassium channel Kir2.1: Clinical and comparative insights. [PDF]

J Biol Chem
Anderson CL, Munuwar S, Walters JK, McWilliams SF, Melnick M, Langer ER, Bereslavskyy I, Milaitis MR, Reilly L, Eckhardt LL.   +9 more
europepmc   +1 more source

Small‐scale variability patterns of DMS and phytoplankton in surface waters of the tropical and subtropical Atlantic, Indian, and Pacific Oceans

, 2015
Sarah-Jeanne Royer, A. Mahajan, M. Galí, E. Saltzman, R. Simó   +4 more
semanticscholar   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

SLR-Net: Lightweight and Accurate Detection of Weak Small Objects in Satellite Laser Ranging Imagery. [PDF]

Sensors (Basel)
Zhu W, Hu J, Gong W, Wang Y, Zhang Y.
europepmc   +1 more source

Measurement of DMS, DMSO, and DMSP in natural waters by automated sequential chemical analysis

, 2015
E. Asher, J. Dacey, Tereza Jarníková, P. Tortell   +3 more
semanticscholar   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

DM Plan

Detailed recommendations for consortium specific data acquisition, storage and publishing.
openaire   +3 more sources

Epigenetic Age Prediction Using N6-Methyladenine in the Buff-Tailed Bumblebee (Bombus terrestris). [PDF]

Aging Cell
Renard T, Boseret M, Aron S.
europepmc   +1 more source

Establishing FRLs using a DMS and comparing to international DRLs in paediatric general X-ray [PDF]

Samuel Montgomery Lilli, Amanda Perdomo
openalex   +1 more source