Results 111 to 120 of about 60,289 (232)
Life, 2018 In recent years, there has been a large increase in the amount of experimental evidence for diverse archaeal organisms, and these findings allow for a comprehensive analysis of archaeal genetic organization.
Antonia Denis +3 more
doaj +1 more source
The Mystery of Two Straight Lines in Bacterial Genome Statistics. Release 2007
, 2007 In special coordinates (codon position--specific nucleotide frequencies) bacterial genomes form two straight lines in 9-dimensional space: one line for eubacterial genomes, another for archaeal genomes. All the 348 distinct bacterial genomes available in
A. Carbone +25 more
core +4 more sources
Archaeal Histone Tetramerization Determines DNA Affinity and the Direction of DNA Supercoiling [PDF]
Journal of Biological Chemistry, 2002 DNA binding and the topology of DNA have been determined in complexes formed by >20 archaeal histone variants and archaeal histone dimer fusions with residue replacements at sites responsible for histone fold dimer:dimer interactions. Almost all of these variants have decreased affinity for DNA.
Marc, F. +3 more
openaire +3 more sources
Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation
The FEBS Journal, EarlyView.This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley +1 more source
Microbiome, 2018 Background Amplicon sequencing methods targeting the 16S rRNA gene have been used extensively to investigate microbial community composition and dynamics in anaerobic digestion.
Jo De Vrieze +3 more
doaj +1 more source
A positive relationship between the abundance of ammonia oxidizing archaea and natural abundance δ15N of ecosystems [PDF]
, 2013 We present a significant relationship between the natural abundance isotopic composition of ecosystem pools and the abundance of a microbial gene. Natural abundance 15N of soils and soil DNA were analysed and compared with archaeal ammonia oxidizer ...
Adair, K +5 more
core +1 more source
Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein
The FEBS Journal, EarlyView.Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley +1 more source
A Unifying Scenario on the Origin and Evolution of Cellular and Viral Domains [PDF]
, 2009 The cellular theory on the nature of life has been one of the first major advancements in biology. Viruses, however, are the most abundant life forms, and their exclusion from mainstream biology and the Tree of Life (TOL) is a major paradox in biology ...
Claudiu I. Bandea
core +1 more source
A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Dunker, A. Keith +6 more
core +2 more sources
The FEBS Journal, EarlyView.Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola +11 more
wiley +1 more source