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Archaeal DNA replication and repair
Current Opinion in Microbiology, 2005Since the first archaeal genome was sequenced, much attention has been focused on the study of these unique microorganisms. We have learnt that although archaeal DNA metabolic processes (replication, recombination and repair) are more similar to the metabolic processes of Eukarya than those of Bacteria, Archaea are not simply 'mini Eukarya'.
Zvi, Kelman, Malcolm F, White
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DNA repeats and archaeal nucleosome positioning
Research in Microbiology, 1999Archaeal histones, homologs of the eucaryal nucleosome core histones, have been identified in the Euryarchaeota. They assemble as tetramers with dsDNA to form archaeal nucleosomes that resemble the central structure of the eucaryal nucleosome formed by the histone (H3-H4)2 tetramer.
K A, Bailey, J N, Reeve
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Mutational analysis of archaeal histone-DNA interactions
Journal of Molecular Biology, 2000Site-specific mutagenesis of the hmfB gene cloned from the archaeon Methanothermus fervidus, followed by expression in Escherichia coli, has been used to generate approximately 90 recombinant (r) variants of the archaeal histone HMfB. The abilities of these variants to form stable archaeal nucleosome-containing complexes with linear pBR322 DNA, and ...
D J, Soares, K, Sandman, J N, Reeve
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Negative constrained DNA supercoiling in archaeal nucleosomes
Molecular Microbiology, 2000Archaeal histones have significant sequence and structural similarity to their eukaryal counterparts. However, whereas DNA is wrapped in negatively constrained supercoils in eukaryal nucleosomes, it has been reported that DNA is positively supercoiled by archaeal nucleosomes.
D, Musgrave, P, Forterre, A, Slesarev
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Archaeal histones: structures, stability and DNA binding
Biochemical Society Transactions, 2004Structures, stability and DNA-binding properties have been established for archaeal histones from mesophiles, thermophiles and hyperthermophiles. Most archaeal histones are simply histone folds that are stabilized by dimer formation. Archaeal histones and the histone folds of the eukaryotic nucleosome core histones share a common ancestry and bind and ...
J N, Reeve +5 more
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Archaeal DNA repair: paradigms and puzzles
Biochemical Society Transactions, 2003It is now generally accepted that the Archaea share many similarities in their information-processing pathways with eukarya. Archaeal and eukaryal DNA replication and transcriptional machineries show particularly striking similarities, and the archaeal processes have been used extensively as simpler models of the much more complex eukaryal ones ...
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Uracil recognition by archaeal family B DNA polymerases
Biochemical Society Transactions, 2003Archaeal family-B DNA polymerases possess a novel uracil-sensing mechanism. A specialized pocket scans the template, ahead of the replication fork, for the presence of uracil; on encountering this base, DNA synthesis is stalled. The structural basis for uracil recognition by polymerases is described and compared with other uracil-recognizing enzymes ...
Connolly BA +3 more
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Archaeal DNA replication: spotlight on a rapidly moving field
Extremophiles, 2002The replication of DNA is a fundamental step in the cell cycle, which must be coordinated with cell division to ensure that the daughter cells inherit the same genomic material as the parental cell. The recently published complete genome sequences of some archaeal species together with preliminary biochemical studies suggest that the Archaea quite ...
BOHLKE K. +3 more
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DNA Damage Detection by an Archaeal Single-stranded DNA-binding Protein
Journal of Molecular Biology, 2005Archaeal DNA repair pathways are not well defined; in particular, there are no convincing candidate proteins for detection of DNA mismatches or the bulky lesions removed by excision repair pathways. Single-stranded DNA-binding proteins (SSBs) play a central role in DNA replication, recombination and repair.
Liza, Cubeddu, Malcolm F, White
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Archaeal physiology: Two modes of a DNA scissor
Nature Microbiology, 2017Structural and functional studies of the archaeum Methanocaldococcus jannaschii Argonaute (MjAgo) reveal a DNA-guided DNA nuclease that is also active without a guide. This unguided activity is suggested to prime MjAgo for its subsequent sequence-specific DNA-silencing role in host defence.
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