Results 1 to 10 of about 2,877,234 (303)

Novel Single-Stranded DNA Circular Viruses in Pericardial Fluid of Patient with Recurrent Pericarditis. [PDF]

Emerg Infect Dis, 2016
To the Editor: Circular replication initiation protein (Rep)–encoding single-stranded DNA (ssDNA) (CRESS-DNA) genomes are found in diverse group II virus families, which all possess a conserved Rep-encoding gene and a nonenveloped icosahedral capsid ...
Halary S, Duraisamy R, Fancello L, Monteil-Bouchard S, Jardot P, Biagini P, Gouriet F, Raoult D, Desnues C.   +8 more
europepmc   +2 more sources

Extrachromosomal circular DNA: a new potential role in cancer progression

Journal of Translational Medicine, 2021
Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles),
Tianyi Wang, Haijian Zhang, Youlang Zhou, Jiahai Shi   +3 more
doaj   +2 more sources

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Journal of Hematology & Oncology, 2020
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types.
Yuanliang Yan, Guijie Guo, Jinzhou Huang, Ming Gao, Qian Zhu, Shuangshuang Zeng, Zhicheng Gong, Zhijie Xu   +7 more
doaj   +2 more sources

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA [PDF]

Emerging Microbes and Infections, 2017
The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue.
Magda Rybicka, Anna Woziwodzka, Tomasz Romanowski, Piotr Stalke, Marcin Dręczewski, Krzysztof Piotr Bielawski   +5 more
doaj   +4 more sources

Circular DNA tumor viruses make circular RNAs [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Circular RNAs (circRNAs) play critical physiologic functions, but it is not known whether human DNA viruses express circRNAs. We surveyed Epstein−Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) tumors and cell lines, and found specific circRNAs expressed from both viruses.
Tuna Toptan, Bizunesh Abere, Michael A. Nalesnik, Steven H. Swerdlow, Sarangarajan Ranganathan, Nara Lee, Kathy H. Shair, Patrick S. Moore, Yuan Chang   +8 more
openaire   +3 more sources

Full-length sequencing of circular DNA viruses and extrachromosomal circular DNA using CIDER-Seq

Nature Protocols, 2020
Circular DNA is ubiquitous in nature in the form of plasmids, circular DNA viruses, and extrachromosomal circular DNA (eccDNA) in eukaryotes. Sequencing of such molecules is essential to profiling virus distributions, discovering new viruses and understanding the roles of eccDNAs in eukaryotic cells.
Devang Mehta, Luc Cornet, Matthias Hirsch-Hoffmann, Syed Shan-e-Ali Zaidi, Hervé Vanderschuren   +4 more
openaire   +6 more sources

Detection and Validation of Circular DNA Fragments Using Nanopore Sequencing

Frontiers in Genetics, 2022
Occurrence of extra-chromosomal circular DNA is a phenomenon frequently observed in tumor cells, and the presence of such DNA has been recognized as a marker of adverse outcome across cancer types.
Alicia Isabell Tüns, Till Hartmann, Simon Magin, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Sven Rahmann, Alexander Schramm, Johannes Köster   +15 more
doaj   +1 more source

DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing

bioRxiv, 2023
Long single-molecular sequencing, such as PacBio circular consensus sequencing (CCS) and nanopore sequencing, is advantageous in detecting DNA 5-methylcytosine (5mC) in CpGs, especially in repetitive genomic regions.
Peng Ni, Fan Nie, Zeyu Zhong, Jinrui Xu, Neng Huang, Jun Zhang, Haochen Zhao, You Zou, Yuanfeng Huang, Jinchen Li, Chuan-Le Xiao, Feng Luo, Jianxin Wang   +12 more
semanticscholar   +1 more source

Engineering a Ligase Binding DNA Aptamer into a Templating DNA Scaffold to Guide the Selective Synthesis of Circular DNAzymes and DNA Aptamers

Journal of the American Chemical Society, 2023
Functional nucleic acids (FNAs), such as DNAzymes and DNA aptamers, can be engineered into circular forms for improved performance. Circular FNAs are promising candidates for bioanalytical and biomedical applications due to their intriguing properties of
Yu-Rong Yan, Dingran Chang, Yongbin Xu, Yangyang Chang, Qiang Zhang, Quan Yuan, B. Salena, Yingfu Li, Meng Liu   +8 more
semanticscholar   +1 more source

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Signal Transduction and Targeted Therapy, 2022
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contributing to ...
Ludi Yang, R. Jia, T. Ge, S. Ge, A. Zhuang, P. Chai, Xianqun Fan   +6 more
semanticscholar   +1 more source