Results 131 to 140 of about 3,017,680 (323)

Genome-Wide Profiling of Circular RNAs in the Rapidly Growing Shoots of Moso Bamboo (Phyllostachys edulis). [PDF]

, 2019
Circular RNAs, including circular exonic RNAs (circRNA), circular intronic RNAs (ciRNA) and exon-intron circRNAs (EIciRNAs), are a new type of noncoding RNAs.
Gao, Yubang, Gu, Lianfeng, Hu, Kaiqiang, Kohnen, Markus V, Lin, Chentao, Liu, Xuqing, Wang, Huihui, Wang, Huiyuan, Wang, Yongsheng, Xi, Feihu, Xu, Xi, Zhang, Hangxiao, Zhang, Zeyu, Zhao, Liangzhen   +13 more
core  

Effects of Circular DNA Length on Transfection Efficiency by Electroporation into HeLa Cells

PLoS ONE, 2016
The ability to produce extremely small and circular supercoiled vectors has opened new territory for improving non-viral gene therapy vectors. In this work, we compared transfection of supercoiled DNA vectors ranging from 383 to 4,548 bp, each encoding ...
Benjamin D. Hornstein, Dany Roman, L. M. Arévalo-Soliz, Melinda A. Engevik, L. Zechiedrich   +4 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A [PDF]

, 2011
DNA-sequence and structure dependence on the formation of minor groove complexes at 5′-XCTAGY-3′ by the short lexitropsin thiazotropsin A are explored based on NMR spectroscopy, isothermal titration calorimetry (ITC), circular dichroism (CD) and ...
Anthony, Anthony, Anthony, Barber, Bergqvist, Blaskó, Borea, Chaires, Chenoweth, Dervan, Dervan, Engel, Freyer, Freyer, Gottesfeld, Haq, Haq, Harris, James, Khalaf, Kwong, Ladbury, Lafont, Marques, Neidle, O'Brien, Pang, Parkinson, Pelton, Pullman, Rodger, Schwabe, Spolar, Suckling, Trauger, Treesuwan, Wemmer, Wemmer, Wittayanarakul   +38 more
core   +2 more sources

Dataset on the effects of spermidine on linking number differences between histone H1-free and histone H1-bound circular polynucleosomes

Data in Brief, 2018
The data presented in this article are related to the research article entitled ''Quantitative determination of linking number differences between circular polynucleosomes and histone H1-bound circular polynucleosomes'' Zhang et al. (in press) [1].
Hao Zhang, Tianhu Li
doaj  

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. [PDF]

, 2007
The mechanism of mitochondrial DNA replication is a subject of intense debate. One model proposes a strand-asynchronous replication in which both strands of the circular genome are replicated semi-independently while the other model proposes both a ...
Goffart, S, Pohjoismäki, JLO, Spelbrink, JN, Wanrooij, S, Yasukawa, T   +4 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Programmed pH-Driven Reversible Association and Dissociation of Interconnected Circular DNA Dimer Nanostructures.

Nano letters (Print), 2016
The switchable pH-driven reversible assembly and dissociation of interlocked circular DNA dimers is presented. The circular DNA dimers are interconnected by pH-responsive nucleic acid bridges. In one configuration, the two-ring nanostructure is separated
Yuwei Hu, Jiangtao Ren, Chun-hua Lu, I. Willner   +3 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

A simple large-scale method for separating closed circular form DNA by gel electrophoresis [PDF]

, 1978
The covalently closed form of circular duplex SV40 DNA was separated from the open and linear form of SV40 DNA by agarose gel electrophoresis in a large-scale gel system.
Hidaka, Hideyuki, Oda, Takuzo, Tanabe, Naoko, Watanabe, Sekiko   +3 more
core   +1 more source