Results 21 to 30 of about 2,877,234 (303)
Proceedings of the National Academy of Sciences, 1998 Using circular DNA to measure the degree of unwinding of the double helix caused by ligand binding was one of the first applications of the specific properties of circular DNA. The approach is conceptually simple. Consider a nicked circular DNA of N base pairs that is bound to molecules of a ligand so that the ratio of bound ligands to base pairs is ...
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Characterization of the DNA binding activity of structural protein VP1 from chicken anaemia virus
BMC Veterinary Research, 2018 Background Chicken anaemia virus (CAV) is commonly found in poultry. VP1 is the sole structural protein of CAV, which is the major component responsible for capsid assembly. The CAV virion consists of the VP1 protein and a viral genome. However, there is
Guan-Hua Lai +7 more
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Single-stranded circular DNA theranostics
Theranostics, 2022 The past decade has witnessed the blossom of nucleic acid therapeutics and diagnostics (theranostics). Unlike conventional small molecule medicines or protein biologics, nucleic acid theranostics have characteristic features such as the intrinsic ability as "information drugs" to code and execute genetic and theranostic information, ready ...
Shen, Tingting +4 more
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ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines
Science Advances, 2020 EccDNAs are hiding in plain sight in conventional ATAC-seq data. Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to intercellular heterogeneity in normal and tumor cells.
Pankaj Kumar +8 more
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Journal of Virology, 2020 Eukaryotic single-stranded (ss) DNA viruses are classified into ten families (Table 1) but many remain 38 unclassified (1, 2).….
M. Krupovic +13 more
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Journal of Medical Signals and Sensors, 2017 Background: The aim of this study was to develop a nucleotide geometrical model of the circular mitochondrial DNA (mt-DNA) structure using Geant4-DNA toolkit to predict the radiation-induced damages such as single-strand breaks (SSB), double-strand ...
Mohammad Bagher Tavakoli +3 more
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Construction of DNA hemicatenanes from two small circular DNA molecules. [PDF]
PLoS ONE, 2015 DNA hemicatenanes, one of the simplest possible junctions between two double stranded DNA molecules, have frequently been mentioned in the literature for their possible function in DNA replication, recombination, repair, and organization in chromosomes ...
Claire Gaillard, François Strauss
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Frontiers in Immunology, 2022 Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded RNA viruses generate functional circular DNAs is still unknown. Using circDNA sequencing, divergent PCR, DNA in
Min Zhu +13 more
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Nanoconfined Circular DNA [PDF]
Biophysical Journal, 2014 Nanofluidic channels have become a versatile tool to manipulate single DNA molecules. They allow investigation of confined single DNA molecules from a fundamental polymer physics perspective as wel ...
Alizadehheidari, Mohammadreza +9 more
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Life, 2018 Propagation of genetic information is a fundamental prerequisite for living cells. We recently developed the replication cycle reaction (RCR), an in vitro reaction for circular DNA propagation, by reconstitution of the replication cycle of the ...
Tomonori Hasebe +3 more
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