Results 341 to 350 of about 662,270 (393)

The mutational landscape of Bacillus subtilis conditional hypermutators shows how proofreading skews DNA polymerase error rates. [PDF]

Nucleic Acids Res
Tanneur I, Dervyn E, Guérin C, Kon Kam King G, Jules M, Nicolas P.   +5 more
europepmc   +1 more source

Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3′-5′ exonuclease and strand-displacement activities.

, 1992
Marı́a S. Soengas, José A. Esteban, José M. Lázaro, António Bernad, Marı́a A. Blasco, M. Salas, Luis Blanco   +6 more
openalex   +1 more source

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors

Advanced Science, EarlyView.
A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan, Scott Lovell, Keith W Vance, Jody M Mason   +3 more
wiley   +1 more source

The Yeast HMGB Protein Hmo1 Is a Multifaceted Regulator of DNA Damage Tolerance. [PDF]

Int J Mol Sci
Huo J, Wei A, Guo N, Wang R, Bi X.
europepmc   +1 more source

Soluble Rous Sarcoma Virus Reverse Transcriptases α, αβ, and β Purified from Insect Cells Are Processive DNA Polymerases That Lack an RNase H 3′ → 5′ Directed Processing Activity

, 1999
Susanne Werner, Birgitta M. Wöhrl
openalex   +1 more source

Virome and Experimental Analysis Reveal Tryptophan‐Like Dissolved Organic Matter Contributes to the Persistence of Plant Viruses in River Water

Advanced Science, EarlyView.
Tryptophan‐like dissolved organic matter (Try‐like DOM), a key component of organic matter in river ecosystems, demonstrates significant protective effects against plant viruses. The protective mechanism operates via a “swimming firewall” mode, whereby free Try‐like DOM attenuates ultraviolet (UV) radiation and scavenges reactive oxygen species ...
Yujie Wang, Ming Chen, Liu Yang, Jun Ma, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen   +7 more
wiley   +1 more source

Structural basis for Polθ-helicase DNA binding and microhomology-mediated end-joining. [PDF]

Nat Commun
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS.   +5 more
europepmc   +1 more source

The role of dinB in UV survival and UV-induced mutagenesis in Escherichia coli [PDF]

, 2009
Lee, Mei-Chong Wendy
core   +1 more source

Mechanisms and Therapeutic Strategies for Minority Cell‐Induced Paclitaxel Resistance and Tumor Progression Mediated by Mechanical Forces

Advanced Science, EarlyView.
This study provides new perspectives into the interactions between mechanical forces and cellular dynamics within the tumor microenvironment, particularly elucidating how minority Paclitaxel‐resistant cancer cells (MRCs) promote tumor progression and treatment resistance through mechanical forces and also providing effective treatment strategies for ...
Xueyan Feng, Di Zhang, Guoxun Wang, Liwei Lu, Feng Feng, Xiuyu Wang, Chanchan Yu, Yahong Chai, Jin Zhang, Wenchao Li, Jing Liu, Hongxia Sun, Li Yao   +12 more
wiley   +1 more source

TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA. [PDF]

Commun Biol
Matsuda S, Nakayama M, Do Y, Ishiuchi T, Yagi M, Wanrooij S, Nakada K, Wei FY, Ichiyanagi K, Sasaki H, Kang D, Yasukawa T.   +11 more
europepmc   +1 more source